Frizzled-8 Explained

Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.^{[1] [2]}

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.

Further reading

• Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J . A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled . J. Biol. Chem. . 271 . 8 . 4468–4476 . 1996 . 8626800 . 10.1074/jbc.271.8.4468 . free .
• Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS . Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action . Proc. Natl. Acad. Sci. U.S.A. . 94 . 13 . 6770–6775 . 1997 . 9192640 . 21233 . 10.1073/pnas.94.13.6770 . 1997PNAS...94.6770F . free .
• Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X . LDL-receptor-related proteins in Wnt signal transduction . Nature . 407 . 6803 . 530–535 . 2000 . 11029007 . 10.1038/35035117 . 2000Natur.407..530T . 4400159 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–1795 . 2001 . 11076863 . 310948 . 10.1101/gr.143000 .
• Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X . Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6 . Curr. Biol. . 11 . 12 . 951–961 . 2001 . 11448771 . 10.1016/S0960-9822(01)00290-1 . 15702819 . free . 2001CBio...11..951S .
• Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ . Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains . Nature . 412 . 6842 . 86–90 . 2001 . 11452312 . 10.1038/35083601 . 2001Natur.412...86D . 4303237 .
• Yao R, Maeda T, Takada S, Noda T . Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled . Biochem. Biophys. Res. Commun. . 286 . 4 . 771–778 . 2001 . 11520064 . 10.1006/bbrc.2001.5430 .
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y . Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) . Ophthalmic Genet. . 25 . 2 . 81–90 . 2004 . 15370539 . 10.1080/13816810490514270 . 32817238 .
• Lu W, Yamamoto V, Ortega B, Baltimore D . Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth . Cell . 119 . 1 . 97–108 . 2004 . 15454084 . 10.1016/j.cell.2004.09.019 . 18567677 . free .

External links

• Web site: Frizzled Receptors: FZD₈ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-04 . 2014-09-03 . https://web.archive.org/web/20140903142749/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3066 . dead .

Notes and References

1. Saitoh T, Hirai M, Katoh M . Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2 . Int J Oncol . 18 . 5 . 991–6 . Apr 2001 . 11295046 . 10.3892/ijo.18.5.991 .
2. Web site: Entrez Gene: FZD8 frizzled homolog 8 (Drosophila).