Frizzled-7 Explained

Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.^{[1] [2] [3]}

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.^[3]

Interactions

Fz-7 has been shown to interact with DLG4.^[4]

Further reading

• Finch PW, He X, Kelley MJ . Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action . Proc. Natl. Acad. Sci. U.S.A. . 94 . 13 . 6770–5 . 1997 . 9192640 . 10.1073/pnas.94.13.6770 . 21233 . etal. 1997PNAS...94.6770F. free .
• Hering H, Sheng M . Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 . FEBS Lett. . 521 . 1–3 . 185–9 . 2002 . 12067714 . 10.1016/S0014-5793(02)02831-4 . 39243103 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Yao R, Natsume Y, Noda T . MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap . Oncogene . 23 . 36 . 6023–30 . 2005 . 15195140 . 10.1038/sj.onc.1207817 . free .
• Omoto S, Hayashi T, Kitahara K . Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) . Ophthalmic Genet. . 25 . 2 . 81–90 . 2004 . 15370539 . 10.1080/13816810490514270 . 32817238 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Vincan E, Darcy PK, Smyth MJ . Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth . Differentiation . 73 . 4 . 142–53 . 2005 . 15901282 . 10.1111/j.1432-0436.2005.00015.x . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . etal. 2005Natur.437.1173R . 4427026 .
• Lim J, Hao T, Shaw C . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . etal. free .
• Vincan E, Darcy PK, Farrelly CA . Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids . Oncogene . 26 . 16 . 2340–52 . 2007 . 17016432 . 10.1038/sj.onc.1210026 . etal. free .
• Struewing IT, Barnett CD, Zhang W . Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1 . Exp. Cell Res. . 313 . 16 . 3526–41 . 2007 . 17716656 . 10.1016/j.yexcr.2007.07.012 . etal.

External links

• Web site: Frizzled Receptors: FZD₇ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-04 . 2016-03-03 . https://web.archive.org/web/20160303205141/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3065 . dead .

Notes and References

1. Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K . A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals . Proc Natl Acad Sci U S A . 95 . 17 . 10164–9 . September 1998. 9707618 . 21479 . 10.1073/pnas.95.17.10164 . 1998PNAS...9510164T . free .
2. Sagara N, Toda G, Hirai M, Terada M, Katoh M . Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 . Biochem Biophys Res Commun . 252 . 1 . 117–22 . December 1998. 9813155 . 10.1006/bbrc.1998.9607 .
3. Web site: Entrez Gene: FZD7 frizzled homolog 7 (Drosophila).
4. Hering . Heike . Sheng Morgan . June 2002. Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 . FEBS Lett. . 521 . 1–3 . 185–9 . Netherlands. 0014-5793. 12067714 . 10.1016/S0014-5793(02)02831-4 . 39243103 . free .