Frizzled-5 Explained

Frizzled-5 (Fz-5) is a protein that in humans is encoded by the FZD5 gene.^{[1] [2] [3]}

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Fz-5 is believed to be the receptor for the Wnt5A ligand.

Further reading

• He X, Saint-Jeannet JP, Wang Y . A member of the Frizzled protein family mediating axis induction by Wnt-5A. . Science . 275 . 5306 . 1652–4 . 1997 . 9054360 . 10.1126/science.275.5306.1652 . 36777692 . etal.
• Finch PW, He X, Kelley MJ . Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. . Proc. Natl. Acad. Sci. U.S.A. . 94 . 13 . 6770–5 . 1997 . 9192640 . 10.1073/pnas.94.13.6770 . 21233 . 1997PNAS...94.6770F . etal. free .
• Tanaka S, Akiyoshi T, Mori M . A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 17 . 10164–9 . 1998 . 9707618 . 10.1073/pnas.95.17.10164 . 21479 . 1998PNAS...9510164T . etal. free .
• Tamai K, Semenov M, Kato Y . LDL-receptor-related proteins in Wnt signal transduction. . Nature . 407 . 6803 . 530–5 . 2000 . 11029007 . 10.1038/35035117 . 2000Natur.407..530T . 4400159 . etal.
• Wiemann S, Weil B, Wellenreuther R . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . etal.
• Yao R, Maeda T, Takada S, Noda T . Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. . Biochem. Biophys. Res. Commun. . 286 . 4 . 771–8 . 2001 . 11520064 . 10.1006/bbrc.2001.5430 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Weidler C, Schaumburger J, Miller LE . Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation. . J. Rheumatol. . 31 . 9 . 1874–5 . 2004 . 15338479 . etal.
• Omoto S, Hayashi T, Kitahara K . Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). . Ophthalmic Genet. . 25 . 2 . 81–90 . 2004 . 15370539 . 10.1080/13816810490514270 . 32817238 . etal.
• Holmen SL, Robertson SA, Zylstra CR, Williams BO . Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein. . Biochem. Biophys. Res. Commun. . 328 . 2 . 533–9 . 2005 . 15694380 . 10.1016/j.bbrc.2005.01.009 .
• Hillier LW, Graves TA, Fulton RS . Generation and annotation of the DNA sequences of human chromosomes 2 and 4. . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . etal. free .
• Blumenthal A, Ehlers S, Lauber J . The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. . Blood . 108 . 3 . 965–73 . 2006 . 16601243 . 10.1182/blood-2005-12-5046 . etal. free .
• Yamamoto H, Komekado H, Kikuchi A . Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. . Dev. Cell . 11 . 2 . 213–23 . 2006 . 16890161 . 10.1016/j.devcel.2006.07.003 . free .
• Katoh Y, Katoh M . Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. . Int. J. Oncol. . 30 . 3 . 751–5 . 2007 . 17273778 . 10.3892/ijo.30.3.751. free .

External links

• Web site: Frizzled Receptors: FZD₅ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-04 . 2016-06-25 . https://web.archive.org/web/20160625040950/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3063 . dead .

Notes and References

1. Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J . A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled . J Biol Chem . 271 . 8 . 4468–76 . Jun 1996 . 8626800 . 10.1074/jbc.271.8.4468 . free .
2. Saitoh T, Hirai M, Katoh M . Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region . Int J Oncol . 19 . 1 . 105–10 . Jun 2001 . 11408929 . 10.3892/ijo.19.1.105.
3. Web site: Entrez Gene: FZD5 frizzled homolog 5 (Drosophila).