FXYD3 explained

FXYD domain-containing ion transport regulator 3 is a protein that in humans is encoded by the FXYD3 gene.^{[1] [2] [3]}

Function

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene may function as a chloride channel or as a chloride channel regulator. Two transcript variants encode two different isoforms of the protein; in addition, transcripts utilizing alternative polyA signals have been described in the literature.

Further reading

• Crowell KJ, Franzin CM, Koltay A, Lee S, Lucchese AM, Snyder BC, Marassi FM . Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics . 1645 . 1 . 15–21 . Jan 2003 . 12535606 . 2917601 . 10.1016/S1570-9639(02)00473-9 .
• Grzmil M, Voigt S, Thelen P, Hemmerlein B, Helmke K, Burfeind P . Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells . International Journal of Oncology . 24 . 1 . 97–105 . Jan 2004 . 14654946 . 10.3892/ijo.24.1.97 .
• Kayed H, Kleeff J, Kolb A, Ketterer K, Keleg S, Felix K, Giese T, Penzel R, Zentgraf H, Büchler MW, Korc M, Friess H . FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth . International Journal of Cancer . 118 . 1 . 43–54 . Jan 2006 . 16003754 . 10.1002/ijc.21257 . 8644783 . free .
• Franzin CM, Yu J, Thai K, Choi J, Marassi FM . Correlation of gene and protein structures in the FXYD family proteins . Journal of Molecular Biology . 354 . 4 . 743–50 . Dec 2005 . 16288923 . 2907130 . 10.1016/j.jmb.2005.10.018 .
• Bibert S, Roy S, Schaer D, Felley-Bosco E, Geering K . Structural and functional properties of two human FXYD3 (Mat-8) isoforms . The Journal of Biological Chemistry . 281 . 51 . 39142–51 . Dec 2006 . 17077088 . 10.1074/jbc.M605221200 . free .
• Arimochi J, Ohashi-Kobayashi A, Maeda M . Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells . Biological & Pharmaceutical Bulletin . 30 . 4 . 648–54 . Apr 2007 . 17409496 . 10.1248/bpb.30.648 . free .

Notes and References

1. Morrison BW, Moorman JR, Kowdley GC, Kobayashi YM, Jones LR, Leder P . Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes . The Journal of Biological Chemistry . 270 . 5 . 2176–82 . Feb 1995 . 7836447 . 10.1074/jbc.270.5.2176 . free .
2. Sweadner KJ, Rael E . The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression . Genomics . 68 . 1 . 41–56 . Aug 2000 . 10950925 . 10.1006/geno.2000.6274 .
3. Web site: Entrez Gene: FXYD3 FXYD domain containing ion transport regulator 3.