FUT9 explained

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT9 gene.^{[1] [2] [3]}

FUT9 is one of several alpha-3-fucosyltransferases that can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides. FUT9 synthesizes the LeX oligosaccharide (CD15), which is expressed in organ buds progressing in mesenchyma during human embryogenesis.[supplied by OMIM]^[4]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Nishihara S, Iwasaki H, Kaneko M . Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue . FEBS Lett. . 462 . 3 . 289–94 . 2000 . 10622713 . 10.1016/S0014-5793(99)01549-5 . 37842289 . etal. free .
• Cailleau-Thomas A, Coullin P, Candelier JJ . FUT4 and FUT9 genes are expressed early in human embryogenesis . Glycobiology . 10 . 8 . 789–802 . 2000 . 10929005 . 10.1093/glycob/10.8.789 . etal. free .
• Nakayama F, Nishihara S, Iwasaki H . CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV . J. Biol. Chem. . 276 . 19 . 16100–6 . 2001 . 11278338 . 10.1074/jbc.M007272200 . etal. free.
• Roos C, Kolmer M, Mattila P, Renkonen R . Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism . J. Biol. Chem. . 277 . 5 . 3168–75 . 2002 . 11698403 . 10.1074/jbc.M107927200 . free .
• Toivonen S, Nishihara S, Narimatsu H . Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile . Glycobiology . 12 . 6 . 361–8 . 2003 . 12107078 . 10.1093/glycob/12.6.361 . etal. free .
• Li H, Kong Y, Yan B . [Regulation by ovarian hormones of alpha 1,3-fucosyltransferase gene (FUT9) expression in human endometrium] . Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao . 34 . 6 . 775–9 . 2003 . 12417923 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Nishihara S, Iwasaki H, Nakajima K . Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression in brain . Glycobiology . 13 . 6 . 445–55 . 2004 . 12626397 . 10.1093/glycob/cwg048 . etal.
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Bogoevska V, Horst A, Klampe B . CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues . Glycobiology . 16 . 3 . 197–209 . 2006 . 16282604 . 10.1093/glycob/cwj057 . etal. free .

Notes and References

1. Kaneko M, Kudo T, Iwasaki H, Ikehara Y, Nishihara S, Nakagawa S, Sasaki K, Shiina T, Inoko H, Saitou N, Narimatsu H . Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX . FEBS Lett . 452 . 3 . 237–42 . Jul 1999 . 10386598 . 10.1016/S0014-5793(99)00640-7 . 21861521 . free .
2. Kaneko M, Kudo T, Iwasaki H, Shiina T, Inoko H, Kozaki T, Saitou N, Narimatsu H . Assignment of the human alpha 1,3-fucosyltransferase IX gene (FUT9) to chromosome band 6q16 by in situ hybridization . Cytogenet Cell Genet . 86 . 3–4 . 329–30 . Jan 2000 . 10575236 . 10.1159/000015329 . 85080516 .
3. Web site: Entrez Gene: FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase).
4. Web site: Entrez Gene: FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase).