FUT7 explained

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT7 gene.^{[1] [2] [3]}

Function

The sialyl Lewis x oligosaccharide determinant is an essential component of leukocyte counterreceptors for E-selectin- (MIM 131210) and P-selectin- (MIM 173610) mediated adhesions of leukocytes. This oligosaccharide molecule is displayed on the surfaces of granulocytes, monocytes, and natural killer cells. Formation of leukocyte adhesions to these selectins is an early and important step in the process that ultimately allows leukocytes to leave the vascular tree and become recruited into lymphoid tissues and sites of inflammation.[supplied by OMIM]

Further reading

• Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB . Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant . The Journal of Biological Chemistry . 269 . 32 . 20806 . August 1994 . 10.1016/S0021-9258(17)32066-5 . 8051184 . free .
• Smith PL, Gersten KM, Petryniak B, Kelly RJ, Rogers C, Natsuka Y, Alford JA, Scheidegger EP, Natsuka S, Lowe JB . Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands . The Journal of Biological Chemistry . 271 . 14 . 8250–9 . April 1996 . 8626519 . 10.1074/jbc.271.14.8250 . free .
• Le Marer N, Palcic MM, Clarke JL, Davies D, Skacel PO . Developmental regulation of alpha 1,3-fucosyltransferase expression in CD34 positive progenitors and maturing myeloid cells isolated from normal human bone marrow . Glycobiology . 7 . 3 . 357–65 . April 1997 . 9147044 . 10.1093/glycob/7.3.357 . free .
• Mas E, Pasqualini E, Caillol N, El Battari A, Crotte C, Lombardo D, Sadoulet MO . Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines . Glycobiology . 8 . 6 . 605–13 . June 1998 . 9592127 . 10.1093/glycob/8.6.605 . free .
• Bengtson P, Larson C, Lundblad A, Larson G, Påhlsson P . Identification of a missense mutation (G329A;Arg(110)--> GLN) in the human FUT7 gene . The Journal of Biological Chemistry . 276 . 34 . 31575–82 . August 2001 . 11404359 . 10.1074/jbc.M104165200 . free .
• de Vries T, Yen TY, Joshi RK, Storm J, van Den Eijnden DH, Knegtel RM, Bunschoten H, Joziasse DH, Macher BA . Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures . Glycobiology . 11 . 5 . 423–32 . May 2001 . 11425803 . 10.1093/glycob/11.5.423 . free .
• Roos C, Kolmer M, Mattila P, Renkonen R . Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism . The Journal of Biological Chemistry . 277 . 5 . 3168–75 . February 2002 . 11698403 . 10.1074/jbc.M107927200 . free .
• Zerfaoui M, Fukuda M, Langlet C, Mathieu S, Suzuki M, Lombardo D, El-Battari A . The cytosolic and transmembrane domains of the beta 1,6 N-acetylglucosaminyltransferase (C2GnT) function as a cis to medial/Golgi-targeting determinant . Glycobiology . 12 . 1 . 15–24 . January 2002 . 11825883 . 10.1093/glycob/12.1.15 . free .
• Hiraiwa N, Yabuta T, Yoritomi K, Hiraiwa M, Tanaka Y, Suzuki T, Yoshida M, Kannagi R . Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element . Blood . 101 . 9 . 3615–21 . May 2003 . 12506041 . 10.1182/blood-2002-07-2301 . free .
• Zisoulis DG, Kansas GS . H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells . The Journal of Biological Chemistry . 279 . 38 . 39495–504 . September 2004 . 15262995 . 10.1074/jbc.M407904200 . free .
• Miyashiro M, Furuya S, Fujishige K, Sugita T . Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by alpha1-3 fucosyltransferase-VII . Biochemical and Biophysical Research Communications . 324 . 1 . 98–107 . November 2004 . 15464988 . 10.1016/j.bbrc.2004.09.025 .
• Martinez M, Joffraud M, Giraud S, Baïsse B, Bernimoulin MP, Schapira M, Spertini O . Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII . The Journal of Biological Chemistry . 280 . 7 . 5378–90 . February 2005 . 15579466 . 10.1074/jbc.M410899200 . free .
• Prorok-Hamon M, Notel F, Mathieu S, Langlet C, Fukuda M, El-Battari A . N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding . The Biochemical Journal . 391 . Pt 3 . 491–502 . November 2005 . 15926890 . 1276950 . 10.1042/BJ20050344 .
• Brown V, Brown RA, Ozinsky A, Hesselberth JR, Fields S . Binding specificity of Toll-like receptor cytoplasmic domains . European Journal of Immunology . 36 . 3 . 742–53 . March 2006 . 16482509 . 2762736 . 10.1002/eji.200535158 .
• Wang QY, Zhang Y, Chen HJ, Shen ZH, Chen HL . Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway . The FEBS Journal . 274 . 2 . 526–38 . January 2007 . 17229154 . 10.1111/j.1742-4658.2006.05599.x . 25250189 . free .

Notes and References

1. Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB . Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant . The Journal of Biological Chemistry . 269 . 24 . 16789–94 . June 1994 . 10.1016/S0021-9258(19)89461-9 . 8207002 . free .
2. Sasaki K, Kurata K, Funayama K, Nagata M, Watanabe E, Ohta S, Hanai N, Nishi T . Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes . The Journal of Biological Chemistry . 269 . 20 . 14730–7 . May 1994 . 10.1016/S0021-9258(17)36686-3 . 8182079 . free .
3. Web site: Entrez Gene: FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase).