FUT6 explained

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.^{[1] [2] [3]}

The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM]^[4]

Further reading

• Weston BW, Smith PL, Kelly RJ, Lowe JB . Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes. . J. Biol. Chem. . 267 . 34 . 24575–84 . 1992 . 10.1016/S0021-9258(18)35803-4 . 1339443 . free .
• Cameron HS, Szczepaniak D, Weston BW . Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. . J. Biol. Chem. . 270 . 34 . 20112–22 . 1995 . 7650030 . 10.1074/jbc.270.34.20112 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Mollicone R, Reguigne I, Fletcher A . Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). . J. Biol. Chem. . 269 . 17 . 12662–71 . 1994 . 10.1016/S0021-9258(18)99927-8 . 8175676 . etal. free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Borsig L, Imbach T, Höchli M, Berger EG . alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles. . Glycobiology . 9 . 11 . 1273–80 . 2000 . 10536043 . 10.1093/glycob/9.11.1273 . free .
• Schnyder-Candrian S, Borsig L, Moser R, Berger EG . Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 15 . 8369–74 . 2000 . 10900002 . 10.1073/pnas.97.15.8369 . 26954 . 2000PNAS...97.8369S . free .
• Kamińska J, Musielak M, Nowicka A . Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G and elastase. . Biochimie . 83 . 8 . 739–42 . 2001 . 11530205 . 10.1016/S0300-9084(01)01306-2 . etal.
• Roos C, Kolmer M, Mattila P, Renkonen R . Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. . J. Biol. Chem. . 277 . 5 . 3168–75 . 2002 . 11698403 . 10.1074/jbc.M107927200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Kanoh A, Ota M, Narimatsu H, Irimura T . Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion. . Biochem. Biophys. Res. Commun. . 303 . 3 . 896–901 . 2003 . 12670495 . 10.1016/S0006-291X(03)00420-0 .
• Martinez-Duncker I, Michalski JC, Bauvy C . Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis. . Glycobiology . 14 . 1 . 13–25 . 2004 . 14514715 . 10.1093/glycob/cwh006 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Higai K, Miyazaki N, Azuma Y, Matsumoto K . Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene. . FEBS Lett. . 580 . 26 . 6069–75 . 2007 . 17054948 . 10.1016/j.febslet.2006.09.073 . 9731951 .

Notes and References

1. Koszdin KL, Bowen BR . The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand . Biochem Biophys Res Commun . 187 . 1 . 152–7 . Oct 1992 . 1520296 . 10.1016/S0006-291X(05)81472-X .
2. McCurley RS, ((Recinos A III)), Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW . Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21 . Genomics . 26 . 1 . 142–6 . Jul 1995 . 7782074 . 10.1016/0888-7543(95)80094-3 .
3. Web site: Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase).
4. Web site: Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase).