FUT4 explained

fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Hgncid:	4015
Symbol:	FUT4
Altsymbols:	CD15, FCT3A, ELFT, SSEA-1, LeX
Entrezgene:	2526
Omim:	104230
Refseq:	NM_002033
Uniprot:	P22083
Ecnumber:	2.4.1.152
Chromosome:	11
Arm:	q
Band:	21

Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific), also known as FUT4, is an enzyme which in humans is encoded by the FUT4 gene.^{[1] [2] [3]}

Function

The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15).^{[4] [5]}

Notes and References

1. Goelz SE, Hession C, Goff D, Griffiths B, Tizard R, Newman B, Chi-Rosso G, Lobb R . ELFT: a gene that directs the expression of an ELAM-1 ligand . Cell . 63 . 6 . 1349–56 . December 1990 . 1702034 . 10.1016/0092-8674(90)90430-M . 905332 .
2. Couillin P, Mollicone R, Grisard MC, Gibaud A, Ravisé N, Feingold J, Oriol R . Chromosome 11q localization of one of the three expected genes for the human alpha-3-fucosyltransferases, by somatic hybridization . Cytogenet. Cell Genet. . 56 . 2 . 108–11 . 1991 . 1672847 . 10.1159/000133061.
3. Reguigne I, James MR, Richard CW, Mollicone R, Seawright A, Lowe JB, Oriol R, Couillin P . The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21 . Cytogenet. Cell Genet. . 66 . 2 . 104–6 . 1994 . 8287679 . 10.1159/000133677.
4. Web site: Entrez Gene: FUT4 .
5. Nakayama F, Nishihara S, Iwasaki H, Kudo T, Okubo R, Kaneko M, Nakamura M, Karube M, Sasaki K, Narimatsu H . CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV . J. Biol. Chem. . 276 . 19 . 16100–6 . May 2001 . 11278338 . 10.1074/jbc.M007272200 . free .