FUT1 explained

Galactoside 2-alpha-L-fucosyltransferase 1 is an enzyme that in humans is encoded by the FUT1 gene.^[1]

The enzyme is involved in the synthesis of the H antigen.

Further reading

• Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gérard G, Oriol R . The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9 . Annals of Human Genetics . 55 . Pt 3 . 225–33 . July 1991 . 1763885 . 10.1111/j.1469-1809.1991.tb00417.x . 30777695 .
• Larsen RD, Ernst LK, Nair RP, Lowe JB . Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen . Proceedings of the National Academy of Sciences of the United States of America . 87 . 17 . 6674–8 . September 1990 . 2118655 . 54599 . 10.1073/pnas.87.17.6674 . 1990PNAS...87.6674L . free .
• Reguigne-Arnould I, Couillin P, Mollicone R, Fauré S, Fletcher A, Kelly RJ, Lowe JB, Oriol R . Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19 . Cytogenetics and Cell Genetics . 71 . 2 . 158–62 . 1995 . 7656588 . 10.1159/000134098 .
• Bruneau N, Lombardo D . Chaperone function of a Grp 94-related protein for folding and transport of the pancreatic bile salt-dependent lipase . The Journal of Biological Chemistry . 270 . 22 . 13524–33 . June 1995 . 7768954 . 10.1074/jbc.270.22.13524 . free .
• Kelly RJ, Ernst LK, Larsen RD, Bryant JG, Robinson JS, Lowe JB . Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals . Proceedings of the National Academy of Sciences of the United States of America . 91 . 13 . 5843–7 . June 1994 . 7912436 . 44093 . 10.1073/pnas.91.13.5843 . 1994PNAS...91.5843K . free .
• Koda Y, Soejima M, Kimura H . Structure and expression of H-type GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase gene (FUT1). Two transcription start sites and alternative splicing generate several forms of FUT1 mRNA . The Journal of Biological Chemistry . 272 . 11 . 7501–5 . March 1997 . 9054453 . 10.1074/jbc.272.11.7501 . free .
• Wagner FF, Flegel WA . Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles . Transfusion . 37 . 3 . 284–90 . March 1997 . 9122901 . 10.1046/j.1537-2995.1997.37397240210.x . 25273202 .
• Kaneko M, Nishihara S, Shinya N, Kudo T, Iwasaki H, Seno T, Okubo Y, Narimatsu H . Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme . Blood . 90 . 2 . 839–49 . July 1997 . 9226185 . 10.1182/blood.V90.2.839. free .
• Koda Y, Soejima M, Johnson PH, Smart E, Kimura H . Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system . Biochemical and Biophysical Research Communications . 238 . 1 . 21–5 . September 1997 . 9299444 . 10.1006/bbrc.1997.7232 .
• Koda Y, Soejima M, Kimura H . Changing transcription start sites in H-type alpha(1,2)fucosyltransferase gene (FUT1) during differentiation of the human erythroid lineage . European Journal of Biochemistry . 256 . 2 . 379–87 . September 1998 . 9760178 . 10.1046/j.1432-1327.1998.2560379.x .
• Roos C, Kolmer M, Mattila P, Renkonen R . Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism . The Journal of Biological Chemistry . 277 . 5 . 3168–75 . February 2002 . 11698403 . 10.1074/jbc.M107927200 . free .
• Yip SP, Chee KY, Chan PY, Chow EY, Wong HF . Molecular genetic analysis of para-Bombay phenotypes in Chinese: a novel non-functional FUT1 allele is identified . Vox Sanguinis . 83 . 3 . 258–62 . October 2002 . 12366770 . 10.1046/j.1423-0410.2002.00184.x . 10397/32501 . 37005881 . free .
• López-Ferrer A, de Bolós C . The expression of human FUT1 in HT-29/M3 colon cancer cells instructs the glycosylation of MUC1 and MUC5AC apomucins . Glycoconjugate Journal . 19 . 1 . 13–21 . January 2002 . 12652076 . 10.1023/A:1022576712961 . 13065601 .
• Shi S, Stanley P . Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways . Proceedings of the National Academy of Sciences of the United States of America . 100 . 9 . 5234–9 . April 2003 . 12697902 . 154328 . 10.1073/pnas.0831126100 . 2003PNAS..100.5234S . free .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–16 . June 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
• Guo ZH, Xiang D, Zhu ZY, Wang JL, Zhang JM, Liu X, Shen W, Chen HP . [Analysis on FUT1 and FUT2 gene of 10 para-Bombay individuals in China] . Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics . 21 . 5 . 417–21 . October 2004 . 15476160 .
• Yan L, Zhu F, Xu X, Hong X, Lv Q . Molecular basis for para-Bombay phenotypes in Chinese persons, including a novel nonfunctional FUT1 allele . Transfusion . 45 . 5 . 725–30 . May 2005 . 15847661 . 10.1111/j.1537-2995.2005.04305.x . 21841537 .
• Mejías-Luque R, López-Ferrer A, Garrido M, Fabra A, de Bolós C . Changes in the invasive and metastatic capacities of HT-29/M3 cells induced by the expression of fucosyltransferase 1 . Cancer Science . 98 . 7 . 1000–5 . July 2007 . 17459061 . 10.1111/j.1349-7006.2007.00484.x . 24079329 . free . 11159511 .

Notes and References

1. Web site: Entrez Gene: FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group).