FUB-APINACA explained

FUB-APINACA (also known as A-FUBINACA according to the EMCCDA framework for naming synthetic cannabinoids^[1] and FUB-AKB48) is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB₁ receptor and has been sold online as a designer drug.^[2] It is an analog of APINACA and 5F-APINACA where the pentyl chain has been replaced with fluorobenzyl.

Pharmacology

FUB-APINACA acts as a full agonist with a binding affinity of 1.06 nM at CB₁ and 0.174 nM at CB₂ cannabinoid receptors.^[3]

Legal status

In the United States, FUB-APINACA was temporarily emergency scheduled by the DEA in 2019.^[4] and made a permanent Schedule I Controlled Substance nationwide on April 7, 2022.^[5] Previously, it was illegal only in Alabama (listed as FUB-AKB48).^[6]

Sweden's public health agency suggested classifying FUB-APINACA as a hazardous substance on November 10, 2014.^[7]

See also

• 5F-ADB
• 5F-AMB
• AB-FUBINACA
• AB-CHFUPYCA
• AB-PINACA
• ADAMANTYL-THPINACA
• ADB-CHMINACA
• ADB-FUBINACA
• ADB-PINACA
• ADBICA
• APP-FUBINACA
• FAB-144
• MDMB-CHMINACA
• MDMB-FUBINACA
• PX-3

Notes and References

1. Pulver B, Fischmann S, Gallegos A,Christie R. EMCDDA framework and practical guidance fornaming synthetic cannabinoids. Drug Test Anal. 2023;15(3):255‐276. doi:10.1002/dta.3403
2. Web site: FUB-AKB48 . Cayman Chemical . 23 July 2015.
3. Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE . Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice . Forensic Toxicology . 34 . 2 . 329–343 . 2016 . 27429655 . 4929166 . 10.1007/s11419-016-0320-2 .
4. Web site: Schedules of Controlled Substances: Temporary Placement of 5F-EDMB-PINACA, 5F-MDMB-PICA, FUB-AKB48, 5F-CUMYL-PINACA, and FUB-144 into Schedule I . Federal Register . 2019-04-16 .
5. Schedules of Controlled Substances: Placement of 5F-EDMB-PINACA, 5FMDMB-PICA, FUB-AKB48, 5F-CUMYLPINACA, and FUB-144 in Schedule I . . 7 April 2022 . 87 . 67 .
6. https://legiscan.com/AL/text/SB333/id/988417/Alabama-2014-SB333-Enrolled.pdf Alabama Senate Bill SB 333: Controlled Substances
7. Web site: Cannabinoider föreslås bli klassade som hälsofarlig vara . Folkhälsomyndigheten . 23 July 2015.