Family Tree DNA explained

FamilyTreeDNA
Foundation:2000
Location:Houston, Texas
Area Served:International
Founder:Bennett Greenspan, Max Blankfeld, and Jim Warren
Industry:Genealogical DNA testing
Parent:MYDNA Inc.

FamilyTreeDNA is a division of Gene by Gene, a commercial genetic testing company based in Houston, Texas. FamilyTreeDNA offers analysis of autosomal DNA, Y-DNA, and mitochondrial DNA to individuals for genealogical purpose. With a database of more than two million records, it is the most popular company worldwide for Y-DNA and mitochondrial DNA, and the fourth most popular for autosomal DNA. In Europe, it is the most common also for autosomal DNA.[1] [2] FamilyTreeDNA as a division of Gene by Gene were acquired by MYDNA, Inc., an Australian company, in January 2021.[3]

History

Concept and founding (2000–2002)

FamilyTreeDNA was founded based on an idea conceived by Bennett Greenspan, a lifelong entrepreneur and genealogy enthusiast. In 1999, Greenspan had entered semi-retirement and was working on his family history. He began work on his mother's Nitz lineage. When faced with a roadblock in his work, he remembered two cases of genetics being used to prove ancestry that had recently been covered by the media. These were a study by University of Arizona researchers showing that many Cohen men from both Ashkenazic and Sephardic groups share the same Y-chromosome and a study that showed that male descendants of a paternal uncle of US President Thomas Jefferson (who presumably shared his Y-chromosome) and male-line descendants of his freed slave Sally Hemings shared the same Y-chromosome and a recent common ancestry.

Greenspan had both Nitz cousins in California and had discovered someone in Argentina with the same ancestral surname and the same ancestral location in Eastern Europe. Wishing to use the same method of DNA comparison for his own genealogy, he contacted Dr. Michael Hammer at the University of Arizona. Greenspan discovered that academic labs did not offer testing directly to the public and that in general direct to consumer testing for genealogy was not commercially available either. Their conversation inspired him to start a company dedicated to using genetics to help solve genealogy mysteries.

It was early 2000 when Greenspan with his business partners Max Blankfeld and Jim Warren officially launched FamilyTreeDNA. Initially, the Arizona Research Labs at the University of Arizona performed all testing for FamilyTreeDNA. FamilyTreeDNA includes among its scientific staff, Dr. Michael Hammer (PhD), one of a team of scientists that first published on the Cohen Modal Haplotype in 1997 in the journal Nature.

FamilyTreeDNA began with a proof in concept group of twenty-four tests that returned results in January. The company began by offering 12 STR marker Y-chromosome tests much like those used in many scientific publications of the time in March 2000. FamilyTreeDNA became widely known for its Y-chromosome STR testing for the Cohen Modal Haplotype.

They added an interface by which genealogists could run surname research studies. The first person to create such a project through the FamilyTreeDNA site was Doug Mumma, who founded the Mumma project. Such projects can also focus on specific regions and niche populations.

Early testing (2000–2006)

The first tests offered by FamilyTreeDNA were Y-chromosome STR and mitochondrial DNA (mtDNA) tests like those used by published academic studies at the time.[4]

FamilyTreeDNA's initial Y-chromosome tests were described as 11 marker tests. They eventually began to call this a 12 STR marker test as one of the STRS (DYS385) almost always had two copies. This they billed as a method to affirm or disprove a genealogical connection on the direct paternal line.

FamilyTreeDNA's first mtDNA tests were for HVR1 (hypervariable region 1) of the mtDNA. Eventually, they added a Plus test that tested for both HVR1 and HVR2.

In the early days, they did not confirm haplogroups for either mtDNA or Y-DNA.

Opening of the Genomics Research Center

In 2006, FamilyTreeDNA bought out the assets of DNA-Fingerprint, which was a German paternity testing company that offered à la carte testing to the genetic genealogy testing community. With this buyout, Thomas and Astrid Krahn, who had owned DNA-Fingerprint, moved to Houston, Texas, and helped open the Genomics Research Center.

The Genomics Research Center initially did testing for many of the same products that had been sold by DNA-Fingerprint. They began to offer individual and panels of Y-chromosome SNP tests using Sanger testing methods. They also offered the mtDNA full genome test and upgrades to it using the Sanger testing method.

Soon came the launch of the Walk Through the Y (WTY) test. The WTY test offered the most adventurous of citizen scientists the chance to seek the discovery of new Y-chromosome SNPs.[5]

Meanwhile, most testing continued to be done at the University of Arizona lab. The demand for additional test types led Greenspan and Blankfeld to move all testing to their own testing lab in Houston, Texas under the Genealogy by Genetics, Ltd. parent company.

Partnerships

Between 2007 and 2010, FamilyTreeDNA forged several new partnerships that allowed them to access additional international markets.

iGENEA

The first of FamilyTreeDNA's new partnerships was with the Switzerland-based iGENEA company. It was formed alongside the closing of DNA-Fingerprint and Thomas Krahn's helping open the Genomic Research Center in Houston. Their website is available in English, French, German, Italian, and Spanish.[6] [7]

African DNA

In late 2007, Henry Louis Gates created African DNA in partnership with FamilyTreeDNA to help promote genetic testing for personal ancestry among African Americans.[8]

DNA Ancestry & Family Origin

DNA Ancestry & Family Origin DNA Ancestry & Family Origin is a genetic genealogy testing partnership between FamilyTreeDNA and Eastern Biotech & Life Sciences. Their website is available in both English and Arabic.[9]

MyHeritage

In November 2008, a dynamic partnership with MyHeritage was launched, allowing users to incorporate DNA testing and advanced family tree technologies into their family history research. MyHeritage is a website offering online, mobile and software platforms for discovering, preserving and sharing family history worldwide.[10]

Acquisition by MYDNA, Inc. (2021)

In January 2021 it was announced that MYDNA, Inc. a Melbourne, Australia, genomics company, had acquired Family Tree DNA and its parent company Gene by Gene. MYDNA, Inc has historically specialized in pharmacogenomics and nutrigenomics.[11] Dr Lior Rauchberger commenced his role as CEO of MYDNA, Inc immediately. While Gene by Gene co-founders Bennett Greenspan and Max Blankfeld joined the MYDNA, Inc Board of Directors.

DNA testing products

Services provided by FamilyTreeDNA are made in own laboratory meeting CLIA and CAP standards and they are based on various biotechnology products, including for example sequencing platform NovaSeq by Illumina, Inc.[12]

Autosomal DNA testing

In May 2010, FamilyTreeDNA launched an autosomal microarray chip based DNA test. They called the new product Family Finder. The initial product used an Affymetrix microarray chip, but FamilyTreeDNA changed to the Illumina OmniExpress chip and retested all customers who had results from the Affymetrix chip for forward compatibility.[13]

Family Finder allows customers to match relatives as distant as about fifth cousins. Family Finder also includes a component called myOrigins. The results of this test provide percentages of a DNA associated with general regions or specific ethnic groups (e.g. Western Europe, Asia, Jewish, Native American, etc.). Notably, unlike other testing companies, they chose to strip out markers for mendelian medical issues,[14] [15] [16] mtDNA results, and Y-DNA SNP results.

Y-DNA testing

The company markets a range of Y-DNA tests. The Y-chromosome is inherited from father to son, so testers can discover relatives with the same patrilineage. In many cultures these relatives will often share the same surname, since surnames are also inherited father to son. These tests cover 37-111 STR markers depending on the test, and vary in price according to the number of markers covered.[13] FTDNA introduced their "Big Y" test in 2013. Big Y tests approximately 15 million locations on the Y chromosome, looking for novel and shared SNPs.[17] By the end of 2021, FTDNA had identified over 50,000 branches in the tree of all Y-DNA results.[18]

mtDNA testing

FamilyTreeDNA also sells mtDNA testing, offering the choice of either a limited hypervariable region test, or a full sequence test of the entire mitochondrial DNA chromosome.[13]

Genographic Project

FamilyTreeDNA staff were instrumental in developing the Geno 2.0 Next Generation product for the second phase of the Genographic Project.[19] Geno 2.0 samples for both public and scientific study were run at the Genomics Research Center in Houston, Texas (operated by FamilyTreeDNA's parent company, Gene by Gene, Ltd.) until 2016, when Geno 2.0 began utilizing Helix for DNA sequencing.[20] [21]

Gene by Gene

See main article: Gene by Gene. In September 2012, Greenspan and Blankfeld restructured FamilyTreeDNA's parent company, Genealogy by Genetics, Ltd. This included their renaming Genealogy by Genetics, Ltd. as Gene by Gene, Ltd. After restructuring, the business consisted of four divisions, one of these being FamilyTreeDNA for genealogical DNA tests. It is Gene by Gene, Ltd. that operates the Genomics Research Center (GRC) lab in Houston, Texas. In January 2021, Gene by Gene was acquired by MYDNA Inc. Gene by Gene now works together with MYDNA improving genomics testing for a broad range of clinical and non-clinical services.

Data policy and usage by law enforcement

In December 2018, FamilyTreeDNA changed its terms of service to allow law enforcement to use their service to identify suspects of "a violent crime" (defined as child abduction, sexual assault or homicide)[22] or identify the remains of victims. The company confirmed it was working with the FBI on at least a handful of cases.[23] [24] [25] As of March 2019, the company instituted a policy allowing its customers to opt out of law enforcement access to their genetic data. All customers were automatically opted in to such exposure except those living in the European Union who were opted out by default.[26] Law enforcement officers will be required to go through a more rigorous process in order to access the database, while customers who opt out of allowing the FBI to access their data will still be able to search for possible relatives as before. “Users now have the ability to opt out of matching with DNA relatives whose accounts are flagged as being created to identify the remains of a deceased individual or a perpetrator of homicide or sexual assault, also referred to as Law Enforcement Matching (LEM),” the company wrote in an email to customers.[27] In May 2019 FamilyTreeDNA prevented access to its Y-DNA database ysearch.org and its mtDNA data base mitosearch making it more difficult for law enforcement agencies to identify crime suspects.[28] In August 2019, FamilyTreeDNA reported that about 50 law enforcement agencies had submitted DNA samples for matching and that almost 150 cases had been submitted. By spring 2020, only around 3% of about 2 million users have opted out.[29] By August 2020, the company helped solve at least 27 cases.[30]

List of arrest or identifications made with FamilyTreeDna

See also

External links

Notes and References

  1. Book: http://www.isogg.org/wiki/Autosomal_DNA_testing_comparison_chart. Autosomal DNA testing comparison chart. ISOGG. 31 July 2016. Family Tree DNA Learning Center.
  2. News: FamilyTreeDNA Admits to Sharing Genetic Data With F.B.I.. New York Times. 5 February 2019. 2019-02-04. Haag. Matthew.
  3. Web site: Mathews. Chris. 2021-01-08. Houston-based Gene by Gene and FamilyTreeDNA acquired by Australian firm. 2021-01-31. Houston Business Journal.
  4. News: FamilyTreeDNA Review - Everything You Need to Know About FTDNA Tests. 2017-08-14. smarterhobby.com. 2017-09-12. en-US.
  5. Web site: Walk Through the Y (WTY) . 2009-08-07 . https://web.archive.org/web/20090425085933/http://www.familytreedna.com/walk-y-application.aspx . 2009-04-25 . dead .
  6. News: Family Tree DNA takes root in Europe. Houston Business Journal . Houston, TX .
  7. http://www.igenea.com/de/impressum iGENEA web site
  8. Web site: Harvard Professor Henry Louis Gates, Jr. Joins Forces With Family Tree DNA To Launch africandna.com . June 23, 2007.
  9. Web site: DNA Ancestry Website, Homepage . June 23, 2013.
  10. Web site: Try our family offer to trace your ancestors using genetics and FamilyTreeDNA . MyHeritage . November 2008.
  11. Web site: Russell. Judy G.. 2021-01-10. DNA winds of change. 2021-01-31. The Legal Genealogist. en-US.
  12. Web site: DNA Testing for Ancestry & Genealogy FamilyTreeDNA . 2023-10-20 . www.familytreedna.com . en.
  13. Web site: DNA Testing Kits for Ancestry & Finding Relatives. familytreedna.com. 15 July 2015.
  14. Web site: Roberta Estes. Promethease – Genetic Health Information Alternative. DNAeXplained - Genetic Genealogy. 11 June 2017. en. 30 December 2013.
  15. Web site: firemylasers. SNP coverage analysis/comparisons (23andme v3/v4, AncestryDNA, FTDNA) • r/23andme. reddit. 15 July 2015. 11 June 2017. en.
  16. Web site: I hate the way they delete data from autosomal test - Family Tree DNA Forums. forums.familytreedna.com. 22 May 2014 . 11 June 2017. en.
  17. Web site: Is BIG Y the only Y-DNA test That You Will Ever Need?. 2015. DNA Testing Choice. 2016-09-01.
  18. Web site: Y-DNA Haplotree Reaches 50,000 Branches, a Milestone for Genealogy. 2021-12-06. FamilyTreeDNA.com blog. 2022-08-14.
  19. 10.1093/gbe/evt066 . 2013 . Elhaik . E. . Greenspan . E. . Staats . S. . Krahn . T. . Tyler-Smith . C. . Xue . Y. . Tofanelli . S. . Francalacci . P. . Cucca . F. . Pagani . L. . Jin . L. . Li . H. . Schurr . T. G. . Greenspan . B. . Spencer Wells . R. . Genographic . Consortium . Genome Biology and Evolution . 5 . 5 . 1021–31 . 23666864 . 3673633 . 8.
  20. https://web.archive.org/web/20130122064832/https://genographic.nationalgeographic.com/about/ Geno 2.0 Next Generation
  21. https://www.helix.com/shop/national-geographic-geno-2-next-generation/ Helix DNA Sequencing and Geno 2.0
  22. News: Customers Handed Over Their DNA. The Company Let the FBI Take a Look.. Marcus. Amy Dockser. 2019-08-22. Wall Street Journal. 2019-08-31. en-US. 0099-9660.
  23. Web site: Greenspan . Bennett . Connecting Families and Saving Lives . FamilyTreeDNA Press Release . February 2, 2019. February 2019 .
  24. News: Hernandez . Salvador . One Of The Biggest At-Home DNA Testing Companies Is Working With The FBI . BuzzFeed News . January 31, 2019 . February 2, 2019.
  25. News: FamilyTreeDNA Admits to Sharing Genetic Data With F.B.I.. Haag. Matthew. 2019-02-04. The New York Times. 2019-02-11. en-US. 0362-4331.
  26. Web site: Horseshoes and Hand Grenades. 2019-03-15. The DNA Geek. en-US. 2019-08-06.
  27. Web site: Home DNA testing company agrees to shield genetic data from FBI. 2019-03-14.
  28. Web site: Golden State Killer Backlash? Public Databases Shutting Down in Wake of Arrest. Augenstein. Seth. 2018-05-24. Forensic Magazine. en. 2019-05-24.
  29. Web site: Your DNA Test Could Crack a Cold Case. 26 December 2020.
  30. texasobserver.org/genetic-genealogy-texas-murder-dna
  31. Web site: DNA Testing Company FamilyTreeDNA Gives FBI Access To Nearly Two Million Profiles. Silva. Precious. 2019-02-04. International Business Times. 2019-02-11.
  32. Web site: Man Charged in Cold Case Rapes of Woman and 9-Year-Old Girl, Accused of Sexually Abusing 3rd Victim: O.C. DA. 15 January 2019.
  33. Web site: Man convicted of California rapes that attorney blamed on defendant's twin . 24 February 2023 .
  34. Web site: Witnesses asked to come forward in cold case murder, suspect arrested in El Paso County. Grewe. Lindsey. 2019-02-21. KKTV 11 News, Colorado Springs, Co. en. 2019-02-22.
  35. Web site: Linda Ann O'Keefe cold case: Murder, sexual assault suspect dies in custody. True Crime Daily. Oct 3, 2022.
  36. Web site: Man accused of 1973 slaying of Linda O'Keefe and child sexual assaults pleads not guilty. Los Angeles Times. 30 March 2019.
  37. Web site: Exclusive: The FBI Had Already Accessed Family Tree DNA's Database Before Cooperation. Augenstein. Seth. 2019-03-19. Forensic Magazine. en. 2019-05-08.
  38. Web site: Jurors convict Westrom in cold case killing . 25 August 2022 .
  39. Web site: Westrom sentenced to life in prison . 9 September 2022 .
  40. News: FamilyTreeDNA Helps Identify Two Victims from the "Texas Killing Fields". 11 April 2019. Cision.
  41. News: Bodies found in the 'killing fields' haunted Southeast Texas for decades. Will new clues lead to a suspect?. Flynn. Meagan. 2019-04-17. The Washington Post.
  42. Web site: Arizona man faces 8 counts in 24-year-old rape cases in San Diego. azcentral. en. 2019-05-24.
  43. Web site: New Details Emerge on Suspect in 1995 Sex Assault Series. Avitabile. Rafael. Ojeda. Artie. NBC 7 San Diego. en. 2019-05-24. Garske. Monica.
  44. Web site: Arizona man pleads guilty to series of knife-point rapes. 18 December 2019.
  45. Web site: 1995 rapist in Pacific Beach pleads guilty - an Arizona man who was linked by DNA evidence to a series of rapes in 1995 in Pacific Beach and elsewhere pleaded guilty on Dec. 16 to committing six rapes. The agreed-upon prison sentence for Christoph.
  46. Web site: Suspect in series of rapes in San Diego, Riverside counties sentenced. 21 February 2020.
  47. Web site: CDCR Public Inmate Locator Disclaimer .
  48. Web site: Judge rejects effort to toss Bortree attempted case. 15 August 2020 .
  49. Web site: DNA helped solve 1993 rape case; county man indicted. Tipple. Bill. 2019-08-20. Peak of Ohio. 2019-09-06.
  50. Web site: Fresh look at evidence, discarded cigarette butt lead to arrest in 1993 cold case attack. Mcentyre. Glen. 2019-08-21. WBNS-10TV Columbus, Ohio. en. 2019-09-06.
  51. Web site: County man sentenced to maximum in cold case. Oct 3, 2022.
  52. Web site: Cold case ends with attempted aggravated murder conviction.
  53. Web site: County man sentenced to maximum in cold case. Oct 3, 2022.
  54. Web site: Defense says case against accused serial predator is too old to prosecute. Mcentyre. Glen. 2019-08-30. WBNS-10TV Columbus, Ohio. en. 2019-09-06.
  55. https://www.examiner.org/news/115677-judge-rules-against-bortree-motion-to-dismiss
  56. Web site: Offender Details .
  57. News: Ohio high court throws out conviction in 26-year cold case . 10Tv.com . 3 November 2022 .
  58. https://web.archive.org/web/20190913182343/https://denver.cbslocal.com/2019/09/10/donald-perea-jeannie-moore-genealogy-dna-murder/ Donald Perea Jeannie Moore Genealogy
  59. Web site: 'God took him before we got the chance': Suspect identified in 1981 killing of 18-year-old woman. 9 September 2019 .
  60. Web site: Ogden man pleads not guilty to slew of sexual assault charges, files motion to dismiss some charges | Courts | standard.net . 2019-12-07 . 2019-12-07 . https://web.archive.org/web/20191207005144/https://www.standard.net/police-fire/courts/ogden-man-pleads-not-guilty-to-slew-of-sexual-assault/article_5a5ff418-b0a1-5994-b5b0-6ca5695ac62b.html . dead .
  61. Web site: 'Clearfield Rapist' avoids death penalty in new murder case, receives life in prison . 4 December 2020 .
  62. Web site: Serial rapist sentenced to life in prison for 2001 murder of Wyoming woman . 7 December 2020 .
  63. News: Serial rapist to spend life in prison for decades-old attacks in northern Utah . April 6, 2020 .
  64. Web site: Trucker arrested in series of decades-old Wyoming and Utah rape cases. 27 September 2019 .
  65. Web site: Finding accused serial rapist Mark Douglas Burns involved DNA, burned down building. 27 September 2019.
  66. Web site: Offender Search .
  67. Web site: A man convicted of murder is the first person in California to be exonerated with the help of genetic genealogy. CNN. 14 February 2020 .
  68. Web site: CA Man Who Spent 14 Years in Prison for Murder Becomes First to be Exonerated with Help of Genetic Genealogy. 14 February 2020.
  69. Web site: New suspect in 1985 El Dorado Hills murder jailed in Placerville. 17 February 2020.
  70. Web site: Murderer sentenced in South Lake Tahoe; Family of victim addresses killer . 28 September 2022 .
  71. Web site: Chapin. Josh. 2020-02-22. Forensic genealogy group helps Cumberland County investigators crack 21-year-old cold case. 2020-11-11. ABC11 Raleigh-Durham. en.
  72. Web site: NC woman gets 12 years in death of infant she left on a road 20 years ago . 11 August 2021 .
  73. Web site: Burke County woman gets 12 years in death of infant she left on a road 20 years ago . 11 August 2021 .
  74. Web site: NC woman gets 12 years in death of infant she left on a road 20 years ago | Sandhills NC .
  75. Web site: Genealogy helps track another Colorado cold case suspect, the oldest one yet. 2020-04-23. KMGH. en. 2020-04-25.
  76. Web site: Genealogy Service Leads to Arrest of Firefighter Charged in Sex Assaults in Vernon, Manchester. 2020-05-28. NBC Connecticut. en. 2020-05-30.
  77. Web site: Family Ancestry Search Connects Longtime Firefighter to Rape Investigation. 2020-05-29. NBC Connecticut. en. 2020-05-30.
  78. Web site: DNA, genealogy led to arrest in series of rapes. 10 June 2020 .
  79. Web site: Former firefighter pleads guilty to four sexual assaults. Journal Inquirer. Staff. Journal Inquirer. 24 June 2022 . 8 December 2022.
  80. Web site: Former Manchester firefighter gets max 25-year sentence in serial rape case. Matthew P. Knox / Journal. Inquirer. Journal Inquirer. 3 September 2022 . 8 December 2022.
  81. Web site: Portland Police Public Information. 2020-05-04. PPB Cold Case Homicide Detectives Identify Suspect in 20 year-old Homicide with Forensic Genealogy-Arrest Made. 2020-11-11. Portland Oregon Police Bureau.
  82. https://web.archive.org/web/20210312021136/https://katu.com/news/local/oregon-man-christopher-lovrien-charged-in-2-killings-that-took-place-2-decades-apart Oregon man Christopher Lovrien charged in 2 killings that took place 2 decades apart
  83. Web site: California woman accused of killing newborn 32 years ago is loving grandma, attorney says. 5 August 2020.
  84. Web site: Lee County John Doe 1984. 2020-10-23. DNA Doe Project Cases. en-US.
  85. Web site: CONFIRMED SIBLING OF SKELETAL REMAINS. 2020-10-23. www.leecountysherifftx.org. en.
  86. Web site: DNA on discarded Vanilla Coke can leads to arrest in 40-year-old Colorado cold case murder . 2 March 2021 .
  87. Web site: 1981 Cold Case: David Dwayne Anderson Arrested for Murder of Sylvia Quayle in Cherry Hills Village . 25 February 2021 .
  88. Web site: 2022-08-04 . Judge sentences killer to life for 1981 murder in Cherry Hills Village: "You will never breathe another free breath" . 2022-12-05 . The Denver Post . en-US.
  89. Web site: DNA on beer cans leads to arrest in 1996 cold case murder of Florida man stabbed 73 times. NBC News. 4 November 2021 .
  90. Web site: Red Wing woman arrested in deaths of two babies found deceased in 1999 and 2003 . 9 May 2022 .
  91. Web site: How genetic genealogy works to solve cold cases, used in recent Red Wing case . 10 May 2022 .
  92. Web site: Red Wing woman pleads guilty to murder of baby found by Mississippi River in 2003 . 25 January 2023 .
  93. Web site: DNA links suspect to 1996 kidnapping, rape of teen girl in Midland County. Cole. Waterman. 3 November 2022. mlive. 8 December 2022.