Formimidoyltransferase cyclodeaminase explained

Formimidoyltransferase cyclodeaminase or formiminotransferase cyclodeaminase (gene symbol FTCD in humans) is a bifunctional enzyme that catalyzes the following reactions:

• conversion of formiminoglutamate and tetrahydrofolate into formiminotetrahydrofolate and glutamate (glutamate formimidoyltransferase activity,)
• subsequent deamination of formiminotetrahydrofolate to 5,10-methenyltetrahydrofolate and ammonia (formimidoyltetrahydrofolate cyclodeaminase activity,)

Its name comes from the two activities it catalyzes.

Role in pathology

Mutations of the FTCD gene cause glutamate formiminotransferase deficiency.^[1]

See also

• Glutamate-1-semialdehyde

Notes and References

1. Web site: Glutamate formiminotransferase deficiency . . August 10, 2016 . NIH . GARD . December 21, 2020 .