FSCN1 explained

Fascin is a protein that in humans is encoded by the FSCN1 gene.^{[1] [2] [3]}

Interactions

FSCN1 has been shown to interact with Low affinity nerve growth factor receptor^[4] and PKC alpha.^[5]

Further reading

• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin . J. Infect. . 24 . 3 . 317–20 . 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4 .
• Yamashiro-Matsumura S, Matsumura F . Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells . J. Biol. Chem. . 260 . 8 . 5087–97 . 1985 . 10.1016/S0021-9258(18)89183-9 . 3886649 . free .
• Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L, Matsumura F, Kieff E, Birkenbach M . Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein . J. Virol. . 68 . 11 . 7320–8 . 1994 . 7933116 . 237173 . 10.1128/JVI.68.11.7320-7328.1994.
• Geraldine Pinkus . Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E . Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein . Am. J. Pathol. . 148 . 2 . 593–600 . 1996 . 8579121 . 1861678 .
• Yamakita Y, Ono S, Matsumura F, Yamashiro S . Phosphorylation of human fascin inhibits its actin binding and bundling activities . J. Biol. Chem. . 271 . 21 . 12632–8 . 1996 . 8647875 . 10.1074/jbc.271.21.12632 . free .
• Lin XH, Grako KA, Burg MA, Stallcup WB . NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration . Mol. Biol. Cell . 7 . 12 . 1977–93 . 1997 . 8970159 . 276044 . 10.1091/mbc.7.12.1977 .
• Ono S, Yamakita Y, Yamashiro S, Matsudaira PT, Gnarra JR, Obinata T, Matsumura F . Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin . J. Biol. Chem. . 272 . 4 . 2527–33 . 1997 . 8999969 . 10.1074/jbc.272.4.2527 . free .
• Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, Said JW . Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation? . Am. J. Pathol. . 150 . 2 . 543–62 . 1997 . 9033270 . 1858289 .
• Ross R, Ross XL, Schwing J, Längin T, Reske-Kunz AB . The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells . J. Immunol. . 160 . 8 . 3776–82 . 1998 . 10.4049/jimmunol.160.8.3776 . 9558080 . free .
• Sonderbye L, Meehan S, Palsson R, Ahsan N, Ladefoged J, Langhoff E . Immunohistochemical study of actin binding protein (p55) in the human kidney . Transplantation . 65 . 7 . 1004–8 . 1998 . 9565110 . 10.1097/00007890-199804150-00025 . free .
• Kempf W, Levi E, Kamarashev J, Kutzner H, Pfeifer W, Petrogiannis-Haliotis T, Burg G, Kadin ME . Fascin expression in CD30-positive cutaneous lymphoproliferative disorders . J. Cutan. Pathol. . 29 . 5 . 295–300 . 2003 . 12100631 . 10.1034/j.1600-0560.2002.290507.x . 31623792 .
• Goncharuk VN, Ross JS, Carlson JA . Actin-binding protein fascin expression in skin neoplasia . J. Cutan. Pathol. . 29 . 7 . 430–8 . 2003 . 12139639 . 10.1034/j.1600-0560.2002.290708.x . 26565797 .
• Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, Sonzogni A, De Manzoni G, Terzi A, Durante E, Bresaola E, Pezzella F, Viale G . Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer . Br. J. Cancer . 88 . 4 . 537–47 . 2003 . 12592367 . 2377175 . 10.1038/sj.bjc.6600731 .
• Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B . Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin . Oncogene . 22 . 23 . 3616–23 . 2003 . 12789270 . 10.1038/sj.onc.1206561 . 13116876 .
• Bros M, Ross XL, Pautz A, Reske-Kunz AB, Ross R . The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer . J. Immunol. . 171 . 4 . 1825–34 . 2003 . 12902483 . 10.4049/jimmunol.171.4.1825 . free .
• Anilkumar N, Parsons M, Monk R, Ng T, Adams JC . Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility . EMBO J. . 22 . 20 . 5390–402 . 2004 . 14532112 . 213775 . 10.1093/emboj/cdg521 .
• Ishikawa R, Sakamoto T, Ando T, Higashi-Fujime S, Kohama K . Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro . J. Neurochem. . 87 . 3 . 676–85 . 2003 . 14535950 . 10.1046/j.1471-4159.2003.02058.x . 927239 .

Notes and References

1. Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI . cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein . DNA Cell Biol . 13 . 8 . 821–7 . Sep 1994 . 8068206 . 10.1089/dna.1994.13.821 .
2. Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J . Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes . Genomics . 65 . 2 . 146–56 . Jul 2000 . 10783262 . 10.1006/geno.2000.6156 .
3. Web site: Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus).
4. Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B . Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin . Oncogene . 22 . 23 . 3616–23 . Jun 2003 . 12789270 . 10.1038/sj.onc.1206561 . 13116876 .
5. Anilkumar N, Parsons M, Monk R, Ng T, Adams JC . Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility . EMBO J. . 22 . 20 . 5390–402 . Oct 2003 . 14532112 . 213775 . 10.1093/emboj/cdg521 .