FRS3 explained

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.^{[1] [2] [3]}

The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.^[4]

Further reading

• Lim YP, Low BC, Lim J . Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling. . J. Biol. Chem. . 274 . 27 . 19025–34 . 1999 . 10383403 . 10.1074/jbc.274.27.19025 . etal. free .
• Ong SH, Guy GR, Hadari YR . FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. . Mol. Cell. Biol. . 20 . 3 . 979–89 . 2000 . 10629055 . 10.1128/MCB.20.3.979-989.2000 . 85215 . etal.
• Yamada M, Suzuki K, Mizutani M . Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system. . J. Biochem. . 130 . 1 . 157–65 . 2001 . 11432792 . 10.1093/oxfordjournals.jbchem.a002955. etal.
• Yan KS, Kuti M, Yan S . FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors. . J. Biol. Chem. . 277 . 19 . 17088–94 . 2002 . 11877385 . 10.1074/jbc.M107963200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ranzi V, Meakin SO, Miranda C . The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins. . Endocrinology . 144 . 3 . 922–8 . 2003 . 12586769 . 10.1210/en.2002-221002 . etal. free .
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Gotoh N, Laks S, Nakashima M . FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. . FEBS Lett. . 564 . 1–2 . 14–8 . 2004 . 15094036 . 10.1016/S0014-5793(04)00287-X . 35571861 . etal.
• Hassel S, Eichner A, Yakymovych M . Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. . Proteomics . 4 . 5 . 1346–58 . 2004 . 15188402 . 10.1002/pmic.200300770 . 6773754 . etal.
• Huang L, Gotoh N, Zhang S . SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. . Biochem. Biophys. Res. Commun. . 324 . 3 . 1011–7 . 2004 . 15485655 . 10.1016/j.bbrc.2004.09.152 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Harada A, Katoh H, Negishi M . Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. . J. Biol. Chem. . 280 . 18 . 18418–24 . 2005 . 15738000 . 10.1074/jbc.M411356200 . free .
• Huang L, Watanabe M, Chikamori M . Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways. . Oncogene . 25 . 49 . 6457–66 . 2006 . 16702953 . 10.1038/sj.onc.1209656 . etal. 23148856 .

Notes and References

1. Wang JK, Xu H, Li HC, Goldfarb M . Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras . Oncogene . 13 . 4 . 721–9 . Oct 1996 . 8761293 .
2. Xu H, Lee KW, Goldfarb M . Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins . J Biol Chem . 273 . 29 . 17987–90 . Aug 1998 . 9660748 . 10.1074/jbc.273.29.17987 . free.
3. Web site: Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3.
4. Web site: Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3.