Fyn-related kinase explained

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.^{[1] [2]}

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.^[2]

Interactions

FRK has been shown to interact with retinoblastoma protein.^[3]

Further reading

• Serfas MS, Tyner AL . Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases. . Oncol. Res. . 13 . 6–10 . 409–19 . 2003 . 12725532 . 10.3727/096504003108748438.
• Craven RJ, Cance WG, Liu ET . The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb. . Cancer Res. . 55 . 18 . 3969–72 . 1995 . 7664264 .
• Cance WG, Craven RJ, Bergman M . Rak, a novel nuclear tyrosine kinase expressed in epithelial cells. . Cell Growth Differ. . 5 . 12 . 1347–55 . 1995 . 7696183 . etal.
• Cance WG, Craven RJ, Weiner TM, Liu ET . Novel protein kinases expressed in human breast cancer. . Int. J. Cancer . 54 . 4 . 571–7 . 1993 . 8099900 . 10.1002/ijc.2910540409 . 23352078 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241. etal. 2002PNAS...9916899M . free .
• Meyer T, Xu L, Chang J . Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase. . Int. J. Cancer . 104 . 2 . 139–46 . 2003 . 12569567 . 10.1002/ijc.10925 . 24095233 . etal.
• Watanabe T, Ohnuma T, Shibata N . No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease. . Neurosci. Lett. . 360 . 1–2 . 109–11 . 2004 . 15082191 . 10.1016/j.neulet.2004.02.046 . 11972631 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Zhang Y, Wolf-Yadlin A, Ross PL . Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. . Mol. Cell. Proteomics . 4 . 9 . 1240–50 . 2005 . 15951569 . 10.1074/mcp.M500089-MCP200 . etal. free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . etal. 2005Natur.437.1173R . 4427026 .

Notes and References

1. Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT . Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene . Gene . 138 . 1–2 . 247–51 . April 1994 . 7510261 . 10.1016/0378-1119(94)90817-6.
2. Web site: Entrez Gene: FRK fyn-related kinase.
3. Craven . R J . Cance W G. Liu E T . September 1995 . The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb . Cancer Res. . 55 . 18 . 3969–72 . UNITED STATES. 0008-5472. 7664264 .