FRAT2 explained

GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene.^{[1] [2] [3]}

The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.^[3]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Bax B, Carter PS, Lewis C . The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. . Structure . 9 . 12 . 1143–52 . 2002 . 11738041 . 10.1016/S0969-2126(01)00679-7 . etal. free .
• Freemantle SJ, Portland HB, Ewings K . Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. . Gene . 291 . 1–2 . 17–27 . 2002 . 12095675 . 10.1016/S0378-1119(02)00594-2 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Stoothoff WH, Cho JH, McDonald RP, Johnson GV . FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation. . J. Biol. Chem. . 280 . 1 . 270–6 . 2005 . 15522877 . 10.1074/jbc.M410061200 . free .

Notes and References

1. Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D . GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis . Cell . 93 . 6 . 1031–41 . Jul 1998 . 9635432 . 10.1016/S0092-8674(00)81208-8 . 17951152 . free .
2. Saitoh T, Moriwaki J, Koike J, Takagi A, Miwa T, Shiokawa K, Katoh M . Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway . Biochem Biophys Res Commun . 281 . 3 . 815–20 . Mar 2001 . 11237732 . 10.1006/bbrc.2001.4421 .
3. Web site: Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2.