FRAT1 explained

Proto-oncogene FRAT1 is a protein that in humans is encoded by the FRAT1 gene.^{[1] [2]}

The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis.^[2]

Further reading

• Li L, Yuan H, Weaver CD . Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. . EMBO J. . 18 . 15 . 4233–40 . 1999 . 10428961 . 10.1093/emboj/18.15.4233 . 1171499 . etal.
• Saitoh T, Katoh M . FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer. . Int. J. Oncol. . 19 . 2 . 311–5 . 2001 . 11445844 . 10.3892/ijo.19.2.311.
• Bax B, Carter PS, Lewis C . The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. . Structure . 9 . 12 . 1143–52 . 2002 . 11738041 . 10.1016/S0969-2126(01)00679-7 . etal. free .
• Saitoh T, Mine T, Katoh M . Molecular cloning and expression of proto-oncogene FRAT1 in human cancer. . Int. J. Oncol. . 20 . 4 . 785–9 . 2002 . 11894125 . 10.3892/ijo.20.4.785.
• Freemantle SJ, Portland HB, Ewings K . Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. . Gene . 291 . 1–2 . 17–27 . 2002 . 12095675 . 10.1016/S0378-1119(02)00594-2 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Hino S, Michiue T, Asashima M, Kikuchi A . Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. . J. Biol. Chem. . 278 . 16 . 14066–73 . 2003 . 12556519 . 10.1074/jbc.M213265200 . free .
• Khambata-Ford S, Liu Y, Gleason C . Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay. . Genome Res. . 13 . 7 . 1765–74 . 2003 . 12805274 . 10.1101/gr.529803 . 403750 . etal.
• Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Wang Y, Hewitt SM, Liu S . Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. . Br. J. Cancer . 94 . 5 . 686–91 . 2006 . 16479254 . 10.1038/sj.bjc.6602988 . 2361213 . etal.
• Hagen T, Cross DA, Culbert AA . FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A. . J. Biol. Chem. . 281 . 46 . 35021–9 . 2007 . 16982607 . 10.1074/jbc.M607003200 . etal. free.

Notes and References

1. Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A . Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas . EMBO J . 16 . 3 . 441–50 . Mar 1997 . 9034327 . 1169648 . 10.1093/emboj/16.3.441 .
2. Web site: Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas.