FRA10AC1 explained

FRA10AC1 is a protein that in humans is encoded by the FRA10AC1 gene.^[1]

Function

The protein encoded by this gene is a nuclear phosphoprotein of unknown function. The 5' UTR of this gene is part of a CpG island and contains a tandem CGG repeat region that normally consists of 8-14 repeats but can expand to over 200 repeats. The expanded allele becomes hyper-methylated and is not transcribed; however, an expanded repeat region has not been associated with any disease phenotype. This gene is found within the rare FRA10A folate-sensitive fragile site.^[1]

Further reading

• Stelzl U, Worm U, Lalowski M . A human protein-protein interaction network: a resource for annotating the proteome. . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . etal. 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Sarafidou T, Kahl C, Martinez-Garay I . Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein. . Genomics . 84 . 1 . 69–81 . 2005 . 15203205 . 10.1016/j.ygeno.2003.12.017 . etal.
• Yu Y, Zhang C, Zhou G . Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. . Genome Res. . 11 . 8 . 1392–403 . 2001 . 11483580 . 10.1101/gr.175501 . 311073 . etal.

Notes and References

1. Web site: Entrez Gene: C10orf4 chromosome 10 open reading frame 4.