FOXA3 explained

Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) is a protein that in humans is encoded by the FOXA3 gene.^{[1] [2]}

Function

HNF-3G is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.^[1]

Further reading

• Corrocher R, Tedesco F, Rabusin P, De Sandre G . Effect of human erythrocyte stromata on complement activation. . Br. J. Haematol. . 29 . 2 . 235–41 . 1975 . 33 . 10.1111/j.1365-2141.1975.tb01817.x. 45491647 .
• Verschuur M, de Jong M, Felida L . A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism. . J. Biol. Chem. . 280 . 17 . 16763–71 . 2005 . 15737987 . 10.1074/jbc.M501973200 . etal. free .
• Clark KL, Halay ED, Lai E, Burley SK . Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. . Nature . 364 . 6436 . 412–20 . 1993 . 8332212 . 10.1038/364412a0 . 1993Natur.364..412C . 4363526 .
• Qian X, Costa RH . Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targeting. . Nucleic Acids Res. . 23 . 7 . 1184–91 . 1995 . 7739897 . 10.1093/nar/23.7.1184 . 306829.
• Rodríguez-Antona C, Bort R, Jover R . Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. . Mol. Pharmacol. . 63 . 5 . 1180–9 . 2003 . 12695546 . 10.1124/mol.63.5.1180. 34628968 . etal.
• Lamba V, Panetta JC, Strom S, Schuetz EG . Genetic predictors of interindividual variability in hepatic CYP3A4 expression. . J. Pharmacol. Exp. Ther. . 332 . 3 . 1088–99 . 2010 . 19934400 . 10.1124/jpet.109.160804 . 2835441.
• Hori Y, Gu X, Xie X, Kim SK . Differentiation of insulin-producing cells from human neural progenitor cells. . PLOS Med. . 2 . 4 . e103 . 2005 . 15839736 . 10.1371/journal.pmed.0020103 . 1087208 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3. etal.
• Motallebipour M, Ameur A, Reddy Bysani MS . Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq. . Genome Biol. . 10 . 11 . R129 . 2009 . 19919681 . 10.1186/gb-2009-10-11-r129 . 3091322. etal . free .
• Zhou B, Zhong Q, Minoo P . Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain. . Am. J. Respir. Cell Mol. Biol. . 38 . 6 . 750–8 . 2008 . 18239190 . 10.1165/rcmb.2007-0350OC . 2396252. etal.
• Navas MA, Vaisse C, Boger S . The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. . Hum. Hered. . 50 . 6 . 370–81 . 2000. 10899756 . 10.1159/000022943. 24745151 . etal.
• Kaestner KH . The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism. . Trends Endocrinol. Metab. . 11 . 7 . 281–5 . 2000 . 10920385 . 10.1016/S1043-2760(00)00271-X. 40600315 .
• Lin B, Morris DW, Chou JY . The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation. . Biochemistry . 36 . 46 . 14096–106 . 1997 . 9369482 . 10.1021/bi9703249 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Dintilhac A, Bernués J . HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. . J. Biol. Chem. . 277 . 9 . 7021–8 . 2002 . 11748221 . 10.1074/jbc.M108417200 . free . 10261/112516 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Kaestner KH, Hiemisch H, Schütz G . Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes. . Mol. Cell. Biol. . 18 . 7 . 4245–51 . 1998 . 9632808 . 10.1128/mcb.18.7.4245. 109008.
• Hromas R, Moore J, Johnston T . Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells. . Blood . 81 . 11 . 2854–9 . 1993 . 8499623 . 10.1182/blood.V81.11.2854.2854. etal. free .

Notes and References

1. Web site: Entrez Gene: forkhead box A3.
2. Mincheva A, Lichter P, Schütz G, Kaestner KH . Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4 . Genomics . 39 . 3 . 417–9 . February 1997 . 9119385 . 10.1006/geno.1996.4477 .