FOSL1 explained

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.^{[1] [2]}

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.^[2]

Interactions

FOSL1 has been shown to interact with USF1 (human gene)^[3] and C-jun.

See also

• AP-1 (transcription factor)

Further reading

• Herdegen T, Leah JD . Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins . Brain Research. Brain Research Reviews . 28 . 3 . 370–490 . Dec 1998 . 9858769 . 10.1016/S0165-0173(98)00018-6 . 11848651 .
• Reddy SP, Mossman BT . Role and regulation of activator protein-1 in toxicant-induced responses of the lung . American Journal of Physiology. Lung Cellular and Molecular Physiology . 283 . 6 . L1161–1178 . Dec 2002 . 12424143 . 10.1152/ajplung.00140.2002 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Tsuchiya H, Fujii M, Niki T, Tokuhara M, Matsui M, Seiki M . Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals . Journal of Virology . 67 . 12 . 7001–7007 . Dec 1993 . 8230424 . 238160 . 10.1128/JVI.67.12.7001-7007.1993.
• Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A . Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13 . Genomics . 18 . 1 . 165 . Oct 1993 . 8276409 . 10.1006/geno.1993.1447 .
• Courseaux A, Grosgeorge J, Gaudray P, Pannett AA, Forbes SA, Williamson C, Bassett D, Thakker RV, Teh BT, Farnebo F, Shepherd J, Skogseid B, Larsson C, Giraud S, Zhang CX, Salandre J, Calender A . Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1) . Genomics . 37 . 3 . 354–365 . Nov 1996 . 8938448 . 10.1006/geno.1996.0570 .
• Arts J, Herr I, Lansink M, Angel P, Kooistra T . Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro . Nucleic Acids Research . 25 . 2 . 311–317 . Jan 1997 . 9016559 . 146448 . 10.1093/nar/25.2.311 .
• Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H . Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity . Oncogene . 14 . 17 . 2091–2098 . May 1997 . 9160889 . 10.1038/sj.onc.1201046 . free .
• Smith CM, Ma NS, Nowak NJ, Shows TB, Gerhard DS . A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13 . Genome Research . 7 . 8 . 835–842 . Aug 1997 . 9267807 . 310665 . 10.1101/gr.7.8.835 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Puntschart A, Wey E, Jostarndt K, Vogt M, Wittwer M, Widmer HR, Hoppeler H, Billeter R . Expression of fos and jun genes in human skeletal muscle after exercise . The American Journal of Physiology . 274 . 1 Pt 1 . C129–37 . Jan 1998 . 9458721 . 10.1152/ajpcell.1998.274.1.C129. free .
• Finzer P, Soto U, Delius H, Patzelt A, Coy JF, Poustka A, zur Hausen H, Rösl F . Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition . Oncogene . 19 . 29 . 3235–3244 . Jul 2000 . 10918580 . 10.1038/sj.onc.1203643 . 37675515 .
• Udalova IA, Kwiatkowski D . Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region . Biochemical and Biophysical Research Communications . 289 . 1 . 25–33 . Nov 2001 . 11708771 . 10.1006/bbrc.2001.5929 .
• Jardine H, MacNee W, Donaldson K, Rahman I . Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1 . The Journal of Biological Chemistry . 277 . 24 . 21158–21166 . Jun 2002 . 11912197 . 10.1074/jbc.M112145200 . free .
• Wang HL, Wang J, Xiao SY, Haydon R, Stoiber D, He TC, Bissonnette M, Hart J . Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin . International Journal of Cancer . 101 . 4 . 301–310 . Oct 2002 . 12209953 . 10.1002/ijc.10630 . 1982862 . free .
• Bergman MR, Cheng S, Honbo N, Piacentini L, Karliner JS, Lovett DH . A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers . The Biochemical Journal . 369 . Pt 3 . 485–496 . Feb 2003 . 12371906 . 1223099 . 10.1042/BJ20020707 .

Notes and References

1. Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R . Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation . Oncogene . 5 . 3 . 249–255 . Mar 1990 . 2107490 .
2. Web site: Entrez Gene: FOSL1 FOS-like antigen 1.
3. Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H . Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity . Oncogene . 14 . 17 . 2091–2098 . May 1997 . 9160889 . 10.1038/sj.onc.1201046 . free .