FNBP4 explained

Formin-binding protein 4 is a protein that in humans is encoded by the FNBP4 gene.^{[1] [2]}

Mutations in this gene have been found associated to cases similar to microphthalmia with limb anomalies (doi: 10.1002/ajmg.a.35983).

Further reading

• Bedford MT . A novel pro-Arg motif recognized by WW domains . J. Biol. Chem. . 275 . 14 . 10359–69 . 2000 . 10744724 . 10.1074/jbc.275.14.10359 . vanc. Sarbassova D . Xu J . 3 . Leder . P . Yaffe . MB . free.
• Bedford MT . Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains . J. Biol. Chem. . 275 . 21 . 16030–6 . 2000 . 10748127 . 10.1074/jbc.M909368199 . vanc. Frankel A . Yaffe MB . 3 . Clarke . S . Leder . P . Richard . S . free.
• Zucconi A . Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1 . J. Mol. Biol. . 307 . 5 . 1329–39 . 2001 . 11292345 . 10.1006/jmbi.2001.4572 . vanc. Dente L . Santonico E . 3 . Castagnoli . Luisa . Cesareni . Gianni .
• Nakayama M, Kikuno R, Ohara O . Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs . Genome Res. . 12 . 11 . 1773–84 . 2003 . 12421765 . 10.1101/gr.406902 . 187542 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Colland F . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . vanc. Jacq X . Trouplin V . 3 . Mougin . C . Groizeleau . C . Hamburger . A . Meil . A . Wojcik . J . Legrain . P .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . vanc. Jedrychowski M . Schwartz D . 3 . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 6 . 1 . 63–70 . Jul 1999 . 10231032 . 10.1093/dnares/6.1.63 . free .
2. Web site: Entrez Gene: FNBP4 formin binding protein 4.