FNBP1 explained

Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene.^{[1] [2]}

Function

The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human.^[3]

Interactions

FNBP1 has been shown to interact with:

• AKAP9,^[4]
• DNM1,^[5]
• Fas ligand^[6]
• SNX2,^[7] and
• TNKS.^[7]

Further reading

• Richnau N, Aspenström P . Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1 . J. Biol. Chem. . 276 . 37 . 35060–70 . 2001 . 11431473 . 10.1074/jbc.M103540200 . free .
• Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O . Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178) . FEBS Lett. . 519 . 1–3 . 50–8 . 2002 . 12023017 . 10.1016/S0014-5793(02)02709-6 . 26765451 .
• Fujita H, Katoh H, Ishikawa Y, Mori K, Negishi M . Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching . J. Biol. Chem. . 277 . 47 . 45428–34 . 2003 . 12244061 . 10.1074/jbc.M208090200 . free .
• Katoh M, Katoh M . FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains . Int. J. Mol. Med. . 11 . 6 . 791–7 . 2004 . 12736724 . 10.3892/ijmm.11.6.791 .
• Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A . The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance . FEBS Lett. . 554 . 1–2 . 10–6 . 2003 . 14596906 . 10.1016/S0014-5793(03)01063-9 . 19552309 .
• Larocca MC, Shanks RA, Tian L, Nelson DL, Stewart DM, Goldenring JR . AKAP350 Interaction with cdc42 Interacting Protein 4 at the Golgi Apparatus . Mol. Biol. Cell . 15 . 6 . 2771–81 . 2004 . 15047863 . 420101 . 10.1091/mbc.E03-10-0757 .
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d .
• Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N . A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis . J. Biol. Chem. . 279 . 38 . 40091–9 . 2004 . 15252009 . 10.1074/jbc.M404899200 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Zhou FL, Zhang WG, Chen G, Zhao WH, Cao XM, Chen YX, Tian W, Liu J, Liu SH . Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma . Cancer Immunol. Immunother. . 55 . 8 . 910–7 . 2006 . 16193335 . 10.1007/s00262-005-0074-x . 24083118 . 11030602 .
• Qian J, Chen W, Lettau M, Podda G, Zörnig M, Kabelitz D, Janssen O . Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL . Cell. Signal. . 18 . 8 . 1327–37 . 2006 . 16318909 . 10.1016/j.cellsig.2005.10.015 .
• Itoh T, Erdmann KS, Roux A, Habermann B, Werner H, De Camilli P . Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins . Dev. Cell . 9 . 6 . 791–804 . 2006 . 16326391 . 10.1016/j.devcel.2005.11.005 . free .
• Tsujita K, Suetsugu S, Sasaki N, Furutani M, Oikawa T, Takenawa T . Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis . J. Cell Biol. . 172 . 2 . 269–79 . 2006 . 16418535 . 2063556 . 10.1083/jcb.200508091 .

Notes and References

1. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 1 . 31–9 . Aug 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
2. Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A . The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia . Proc Natl Acad Sci U S A . 98 . 15 . 8756–61 . Jul 2001 . 11438682 . 37508 . 10.1073/pnas.121433898 . 2001PNAS...98.8756F . free .
3. Web site: Entrez Gene: FNBP1 formin binding protein 1.
4. Larocca MC, Shanks RA, Tian L, Nelson DL, Stewart DM, Goldenring JR . AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus . Mol. Biol. Cell . 15 . 6 . 2771–81 . Jun 2004 . 15047863 . 420101 . 10.1091/mbc.E03-10-0757 .
5. Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N . A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis . J. Biol. Chem. . 279 . 38 . 40091–9 . Sep 2004 . 15252009 . 10.1074/jbc.M404899200 . free .
6. Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O . Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178) . FEBS Lett. . 519 . 1–3 . 50–8 . May 2002 . 12023017 . 10.1016/s0014-5793(02)02709-6. 26765451 .
7. Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A . The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance . FEBS Lett. . 554 . 1–2 . 10–6 . Nov 2003 . 14596906 . 10.1016/s0014-5793(03)01063-9. 19552309 .