FMR1-AS1 gene explained

In molecular biology, FMR1 antisense RNA 1 (FMR1-AS1), also known as ASFMR1 or FMR4, is a long non-coding RNA. The FMR1-AS1 gene overlaps, and is antisense to, the CGG repeat region of the FMR1 gene.[1] Its expression is upregulated in fragile X syndrome premutation carriers, and silenced in patients with fragile X syndrome.[2] FMR1-AS1 has an anti-apoptotic function.

See also

Notes and References

  1. Ladd PD, Smith LE, Rabaia NA, Moore JM, Georges SA, Hansen RS . An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals. . Hum Mol Genet . 2007 . 16 . 24 . 3174–3187 . 17921506 . 10.1093/hmg/ddm293 . etal. free .
  2. Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C . A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. . PLOS ONE . 2008 . 3 . 1 . e1486 . 18213394 . 10.1371/journal.pone.0001486 . 2194623 . 2008PLoSO...3.1486K . free .

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