FMN reductase explained

FMN reductase Riboflavin mononucleotide reductase
Ec Number:	1.5.1.29
Cas Number:	64295-83-6
Go Code:	0008752

In enzymology, an FMN reductase is an enzyme that catalyzes the chemical reaction

FMNH₂ + NAD(P)+

\rightleftharpoons FMN + NAD(P)H + H⁺

The 3 substrates of this enzyme are FMNH2, NAD⁺, and NADP⁺, whereas its 4 products are FMN, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is FMNH2:NAD(P)+ oxidoreductase. Other names in common use include NAD(P)H-FMN reductase, NAD(P)H-dependent FMN reductase, NAD(P)H:FMN oxidoreductase, NAD(P)H:flavin oxidoreductase, NAD(P)H2 dehydrogenase (FMN), NAD(P)H2:FMN oxidoreductase, SsuE, riboflavin mononucleotide reductase, flavine mononucleotide reductase, riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide, (phosphate)) reductase, flavin mononucleotide reductase, and riboflavine mononucleotide reductase.

References

• Duane W, Hastings JW . 1975 . Flavin mononucleotide reductase of luminous bacteria . Mol. Cell. Biochem. . 6 . 53 - 64 . 47604 . 10.1007/BF01731866 . 1 .
• Fisher J, Spencer R, Walsh C . 1976 . Enzyme-catalyzed redox reactions with the flavin analogues 5-deazariboflavin, 5-deazariboflavin 5'-phosphate, and 5-deazariboflavin 5'-diphosphate, 5' leads to 5'-adenosine ester . Biochemistry . 15 . 1054 - 64 . 3207 . 10.1021/bi00650a016 . 5 .
• Tu SC, Becvar JE, Hastings JW . 1979 . Kinetic studies on the mechanism of bacterial NAD(P)H:flavin oxidoreductase . Arch. Biochem. Biophys. . 193 . 110 - 6 . 222213 . 10.1016/0003-9861(79)90013-4 . 1 .
• Liu M, Lei B, Ding Q, Lee JC, Tu SC . 1997 . Vibrio harveyi NADPH:FMN oxidoreductase: preparation and characterization of the apoenzyme and monomer-dimer equilibrium . Arch. Biochem. Biophys. . 337 . 89 - 95 . 8990272 . 10.1006/abbi.1996.9746 . 1 .
• Lei B, Tu SC . 1998 . Mechanism of reduced flavin transfer from Vibrio harveyi NADPH-FMN oxidoreductase to luciferase . Biochemistry . 37 . 14623 - 9 . 9772191 . 10.1021/bi981841+. 41 .
• Tang CK, Jeffers CE, Nichols JC, Tu SC . 2001 . Flavin specificity and subunit interaction of Vibrio fischeri general NAD(P)H-flavin oxidoreductase FRG/FRase I . Arch. Biochem. Biophys. . 392 . 110 - 6 . 11469801 . 10.1006/abbi.2001.2396 . 1 .
• Ingelman M, Ramaswamy S, Niviere V, Fontecave M, Eklund H . 1999 . Crystal structure of NAD(P)H:flavin oxidoreductase from Escherichia coli . Biochemistry . 38 . 7040 - 9 . 10353815 . 10.1021/bi982849m . 22 .
• Eichhorn E, van der Ploeg JR, Leisinger T . 1999 . Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli . J. Biol. Chem. . 274 . 26639 - 46 . 10480865 . 10.1074/jbc.274.38.26639 . 38 . free .