FMNL2 explained

Formin-like protein 2 is a protein that in humans is encoded by the FMNL2 gene.[1] [2]

Expression

Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described.[1] The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2[3]) is regulated through autoinhibition, and may become activated through Rho proteins.[4] The FMNL2 gene is expressed in multiple human tissues.[5]

Function

Formin-like protein 2 is a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.[1]

Clinical significance

FMNL2 expression is considerably higher in colorectal cancer tumors compared to normal tissue.[6]

Clinical studies showed that single nucleotide polymorphisms in the FMNL2 gene are associated with cardio and cerebrovascular risk factors and Alzheimer's disease[7] FMNL2 links vascular disease to increased risk of Alzheimer's disease by regulating the interaction between astrocytes and blood vessels in healthy and Alzheimer's disease brains.[8]

See also

Notes and References

  1. Web site: Entrez Gene: FMNL2 formin-like 2.
  2. Katoh M, Katoh M . Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico . Int. J. Oncol. . 22 . 5 . 1161–8 . May 2003 . 12684686 . 10.3892/ijo.22.5.1161.
  3. Web site: formin-like protein 2 [Homo sapiens] ]. NCBI Reference Sequence: NP_443137.2 . National Center for Biotechnology Information, U.S. National Library of Medicine .
  4. Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R . Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC . Oncogene . 29 . 16 . 2441–8 . April 2010 . 20101212 . 10.1038/onc.2009.515 . free .
  5. Gardberg M, Talvinen K, Kaipio K, Iljin K, Kampf C, Uhlen M, Carpén O . Characterization of Diaphanous-related formin FMNL2 in human tissues . BMC Cell Biol. . 11. 55 . 2010 . 20633255 . 2912821 . 10.1186/1471-2121-11-55 . free .
  6. Zhu XL, Liang L, Ding YQ . Overexpression of FMNL2 is closely related to metastasis of colorectal cancer . Int J Colorectal Dis . 23 . 11 . 1041–7 . November 2008 . 18665374 . 10.1007/s00384-008-0520-2 . 22119273 .
  7. Lee AJ, Raghavan NS, Bhattarai P, Siddiqui T, Sariya S, Reyes-Dumeyer D, Flowers XE, Cardoso SA, De Jager PL, Bennett DA, Schneider JA, Menon V, Wang Y, Lantigua RA, Medrano M, Rivera D, Jiménez-Velázquez IZ, Kukull WA, Brickman AM, Manly JJ, Tosto G, Kizil C, Vardarajan BN, Mayeux R . 6 . FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease . Acta Neuropathologica . May 2022 . 144 . 1 . 59–79 . 35608697 . 10.1007/s00401-022-02431-6 . 9217776 .
  8. Web site: Missing Link Between Alzheimer's and Vascular Disease Found?. 24 May 2022.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "FMNL2".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.