FLVCR2 explained
Feline leukemia virus subgroup C cellular receptor family, member 2 is a protein that in humans is encoded by the FLVCR2 gene.[1]
Function
This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1 (FLVCR1), the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome.
Further reading
- Wimer BM . Letter: Remission of lymphoblastic leukaemia . Lancet . 1 . 7954 . Feb 1976 . 55640 . 316 . 10.1016/s0140-6736(76)91461-6. 54424023 .
- Brasier G, Tikellis C, Xuereb L, Craigie J, Casley D, Kovacs CS, Fudge NJ, Kalnins R, Cooper ME, Wookey PJ . Novel hexad repeats conserved in a putative transporter with restricted expression in cell types associated with growth, calcium exchange and homeostasis . Experimental Cell Research . 293 . 1 . Feb 2004 . 14729055 . 31–42 . 10.1016/j.yexcr.2003.10.002.
- Duffy SP, Shing J, Saraon P, Berger LC, Eiden MV, Wilde A, Tailor CS . The Fowler syndrome-associated protein FLVCR2 is an importer of heme . Molecular and Cellular Biology . 30 . 22 . Nov 2010 . 20823265 . 10.1128/MCB.00690-10 . 5318–24 . 2976379.
- Meyer E, Ricketts C, Morgan NV, Morris MR, Pasha S, Tee LJ, Rahman F, Bazin A, Bessières B, Déchelotte P, Yacoubi MT, Al-Adnani M, Marton T, Tannahill D, Trembath RC, Fallet-Bianco C, Cox P, Williams D, Maher ER . Mutations in FLVCR2 are associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Fowler syndrome) . American Journal of Human Genetics . 86 . 3 . Mar 2010 . 20206334 . 10.1016/j.ajhg.2010.02.004 . 471–8 . 2833392.
- Brown JK, Fung C, Tailor CS . Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1 . Journal of Virology . 80 . 4 . Feb 2006 . 16439531 . 10.1128/JVI.80.4.1742-1751.2006 . 1367145 . 1742–1751.
- Thomas S, Encha-Razavi F, Devisme L, Etchevers H, Bessieres-Grattagliano B, Goudefroye G, Elkhartoufi N, Pateau E, Ichkou A, Bonnière M, Marcorelle P, Parent P, Manouvrier S, Holder M, Laquerrière A, Loeuillet L, Roume J, Martinovic J, Mougou-Zerelli S, Gonzales M, Meyer V, Wessner M, Feysot CB, Nitschke P, Leticee N, Munnich A, Lyonnet S, Wookey P, Gyapay G, Foliguet B, Vekemans M, Attié-Bitach T . High-throughput sequencing of a 4.1 Mb linkage interval reveals FLVCR2 deletions and mutations in lethal cerebral vasculopathy . Human Mutation . 31 . 10 . Oct 2010 . 20690116 . 10.1002/humu.21329 . 1134–41. 20452899 .
Notes and References
- Web site: Entrez Gene: Feline leukemia virus subgroup C cellular receptor family, member 2 . NCBI.
