FLII explained

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.^{[1] [2]}

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.^[3] The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.^[4]

Interactions

FLII has been shown to interact with LRRFIP1^{[5] [6]} and TRAF interacting protein.^[7]

Further reading

• Campbell HD, Schimansky T, Claudianos C . The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans. . Proc. Natl. Acad. Sci. U.S.A. . 90 . 23 . 11386–90 . 1994 . 8248259 . 10.1073/pnas.90.23.11386 . 47987 . etal. 1993PNAS...9011386C. free .
• Campbell HD, Fountain S, Young IG . Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. . Genomics . 42 . 1 . 46–54 . 1997 . 9177775 . 10.1006/geno.1997.4709 . etal.
• Liu YT, Yin HL . Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. . J. Biol. Chem. . 273 . 14 . 7920–7 . 1998 . 9525888 . 10.1074/jbc.273.14.7920 . free .
• Wilson SA, Brown EC, Kingsman AJ, Kingsman SM . TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I. . Nucleic Acids Res. . 26 . 15 . 3460–7 . 1998 . 9671805 . 10.1093/nar/26.15.3460 . 147727 .
• Fong KS, de Couet HG . Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system. . Genomics . 58 . 2 . 146–57 . 1999 . 10366446 . 10.1006/geno.1999.5817 .
• Davy DA, Campbell HD, Fountain S . The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases. . J. Cell Sci. . 114 . Pt 3 . 549–62 . 2001 . 10.1242/jcs.114.3.549 . 11171324 . etal.
• Campbell HD, Fountain S, McLennan IS . Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. . Mol. Cell. Biol. . 22 . 10 . 3518–26 . 2002 . 11971982 . 10.1128/MCB.22.10.3518-3526.2002 . 133791 . etal.
• Bi W, Yan J, Stankiewicz P . Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. . Genome Res. . 12 . 5 . 713–28 . 2002 . 11997338 . 10.1101/gr.73702 . 186594 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Gevaert K, Goethals M, Martens L . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 . etal.
• Lee YH, Campbell HD, Stallcup MR . Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. . Mol. Cell. Biol. . 24 . 5 . 2103–17 . 2004 . 14966289 . 10.1128/MCB.24.5.2103-2117.2004 . 350567 .
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . etal. 2004PNAS..10112130B . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Wang T, Chuang TH, Ronni T . Flightless I homolog negatively modulates the TLR pathway. . J. Immunol. . 176 . 3 . 1355–62 . 2006 . 16424162 . 10.4049/jimmunol.176.3.1355. etal. free .
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .

Notes and References

1. Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR . The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2 . Am J Hum Genet . 56 . 1 . 175–82 . Feb 1995 . 7825574 . 1801336 .
2. Web site: Entrez Gene: FLII flightless I homolog (Drosophila).
3. Ghoshdastider U, Popp D, Burtnick LD, Robinson RC . The expanding superfamily of gelsolin homology domain proteins . Cytoskeleton . 70 . 11 . 775–95 . 2013 . 24155256 . 10.1002/cm.21149 . 205643538 .
4. Web site: Entrez Gene: FLII flightless I homolog (Drosophila).
5. 10.1074/jbc.273.14.7920 . Liu . Y T . Yin H L . Apr 1998 . Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies . J. Biol. Chem. . 273 . 14 . 7920–7 . 0021-9258. 9525888 . free .
6. Fong . K S . de Couet H G . Jun 1999 . Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system . Genomics . 58 . 2 . 146–57 . 0888-7543. 10366446 . 10.1006/geno.1999.5817 .
7. 10.1093/nar/26.15.3460 . Wilson . S A . Brown E C . Kingsman A J . Kingsman S M . Aug 1998 . TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I . Nucleic Acids Res. . 26 . 15 . 3460–7 . 0305-1048. 9671805 . 147727 .