FKBPL explained

FK506-binding protein like, also known as FKBPL, is a protein that in humans is encoded by the FKBPL gene.^[1]

Function

FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle.^[2]

FKBPL is involved in cellular response to stress. It was first isolated in 1999 and was initially named DIR1.^[3] It was later reclassified because of its homology to the FKBP family of proteins and was renamed FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised p21 termed it Wisp39.^[4]

It is known to interact with Hsp90, glucocorticoid receptor and dynamitin and may play a role in signalling, like other FKBPs.^[5]

FKBPL has also been shown to influence estrogen receptor signalling and can have a determinant effect on response to the breast cancer drug tamoxifen.^[6]

Notes and References

1. Robson TA, Lohrer H, Bailie JR, Hirst DG, Joiner MC, Arrand JE . Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line . Biochem. Soc. Trans. . 25 . 1 . 335–42 . February 1997 . 9056895 . 10.1042/bst0250335.
2. Web site: Entrez Gene: FKBPL .
3. Robson T, Joiner MC, Wilson GD, McCullough W, Price ME, Logan I, Jones H, McKeown SR, Hirst DG . A novel human stress response-related gene with a potential role in induced radioresistance . Radiat. Res. . 152 . 5 . 451–61 . November 1999 . 10521921 . 10.2307/3580140. 3580140. 1999RadR..152..451R .
4. Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A . Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein . Mol. Cell . 17 . 2 . 237–49 . January 2005 . 15664193 . 10.1016/j.molcel.2004.11.049 . free .
5. McKeen HD, McAlpine K, Valentine A, Quinn DJ, McClelland K, Byrne C, O'Rourke M, Young S, Scott CJ, McCarthy HO, Hirst DG, Robson T . A novel FK506-like binding protein (FKBPL) interacts with the glucocorticoid receptor and regulates steroid receptor signalling . Endocrinology . 149. 11. 5724–34. July 2008 . 18669603 . 10.1210/en.2008-0168 . 32563192 .
6. McKeen HD, Byrne C, Jithesh PV, Donley C, Valentine A, Yakkundi A, O'Rourke M, Swanton C, McCarthy HO, Hirst DG, Robson T . FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy . Cancer Res. . 70 . 3 . 1090–100 . February 2010 . 20103631 . 10.1158/0008-5472.CAN-09-2515 . free .