FKBP10 explained

FK506-binding protein 10 is a protein that in humans is encoded by the FKBP10 gene.^{[1] [2] [3]}

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase family. It is located in endoplasmic reticulum and acts as molecular chaperones. Two alternatively spliced variants, which encode different isoform, are reported.

Further reading

• Patterson CE, Gao J, Rooney AP, Davis EC . Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family . Genomics . 79 . 6 . 881–9 . 2002 . 12036304 . 10.1006/geno.2002.6777 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Zhang H, Li XJ, Martin DB, Aebersold R . Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry . Nat. Biotechnol. . 21 . 6 . 660–6 . 2003 . 12754519 . 10.1038/nbt827 . 581283 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Otsuki T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . vanc. Ota T . Nishikawa T . 3 . Hayashi . K . Suzuki . Y . Yamamoto . J . Wakamatsu . A . Kimura . K . Sakamoto . K . free .
• Foster LJ . Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC) . J. Proteome Res. . 5 . 1 . 64–75 . 2006 . 16396496 . 10.1021/pr0502626 . vanc. Rudich A . Talior I . 3 . Patel . Nish . Huang . Xudong . Furtado . L. Michelle . Bilan . Philip J. . Mann . Matthias . Klip . Amira .

Notes and References

1. Patterson CE, Schaub T, Coleman EJ, Davis EC . Developmental Regulation of FKBP65: An ER-localized Extracellular Matrix Binding-Protein . Mol Biol Cell . 11 . 11 . 3925–35 . Feb 2001 . 11071917 . 15047 . 10.1091/mbc.11.11.3925.
2. Ishikawa Y, Vranka J, Wirz J, Nagata K, Bachinger HP . The rough endoplasmic reticulum-resident FK506-binding protein FKBP65 is a molecular chaperone that interacts with collagens . J Biol Chem . 283 . 46 . 31584–90 . Nov 2008 . 18786928 . 10.1074/jbc.M802535200 . free .
3. Web site: Entrez Gene: FKBP10 FK506 binding protein 10, 65 kDa.