RB1CC1 explained

RB1-inducible coiled-coil protein 1 is a protein that in humans is encoded by the RB1CC1 gene.^{[1] [2] [3] [4]}

Interactions

RB1CC1 has been shown to interact with PTK2B,^[5] ASK1^[6] and PTK2.^[5]

Further reading

• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain . DNA Research . 3 . 5 . 321–9, 341–54 . Oct 1996 . 9039502 . 10.1093/dnares/3.5.321 . free .
• Ueda H, Abbi S, Zheng C, Guan JL . Suppression of Pyk2 kinase and cellular activities by FIP200 . The Journal of Cell Biology . 149 . 2 . 423–30 . Apr 2000 . 10769033 . 2175150 . 10.1083/jcb.149.2.423 .
• Chano T, Kontani K, Teramoto K, Okabe H, Ikegawa S . Truncating mutations of RB1CC1 in human breast cancer . Nature Genetics . 31 . 3 . 285–8 . Jul 2002 . 12068296 . 10.1038/ng911 . 23884140 .
• Chano T, Ikegawa S, Saito-Ohara F, Inazawa J, Mabuchi A, Saeki Y, Okabe H . Isolation, characterization and mapping of the mouse and human RB1CC1 genes . Gene . 291 . 1–2 . 29–34 . May 2002 . 12095676 . 10.1016/S0378-1119(02)00585-1 .
• Chano T, Saeki Y, Serra M, Matsumoto K, Okabe H . Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells . The American Journal of Pathology . 161 . 2 . 359–64 . Aug 2002 . 12163359 . 1850752 . 10.1016/S0002-9440(10)64190-9 .
• Abbi S, Ueda H, Zheng C, Cooper LA, Zhao J, Christopher R, Guan JL . Regulation of focal adhesion kinase by a novel protein inhibitor FIP200 . Molecular Biology of the Cell . 13 . 9 . 3178–91 . Sep 2002 . 12221124 . 124151 . 10.1091/mbc.E02-05-0295 .
• Kontani K, Chano T, Ozaki Y, Tezuka N, Sawai S, Fujino S, Saeki Y, Okabe H . RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cells . International Journal of Molecular Medicine . 12 . 5 . 767–9 . Nov 2003 . 14533007 . 10.3892/ijmm.12.5.767 .
• Bamba N, Chano T, Taga T, Ohta S, Takeuchi Y, Okabe H . Expression and regulation of RB1CC1 in developing murine and human tissues . International Journal of Molecular Medicine . 14 . 4 . 583–7 . Oct 2004 . 15375585 . 10.3892/ijmm.14.4.583 .
• Watanabe R, Chano T, Inoue H, Isono T, Koiwai O, Okabe H . Rb1cc1 is critical for myoblast differentiation through Rb1 regulation . Virchows Archiv . 447 . 3 . 643–8 . Sep 2005 . 15968549 . 10.1007/s00428-004-1183-1 . 21517958 .
• Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL . Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control . The Journal of Cell Biology . 170 . 3 . 379–89 . Aug 2005 . 16043512 . 2171462 . 10.1083/jcb.200411106 .
• Melkoumian ZK, Peng X, Gan B, Wu X, Guan JL . Mechanism of cell cycle regulation by FIP200 in human breast cancer cells . Cancer Research . 65 . 15 . 6676–84 . Aug 2005 . 16061648 . 10.1158/0008-5472.CAN-04-4142 . free .
• Chano T, Saji M, Inoue H, Minami K, Kobayashi T, Hino O, Okabe H . Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation . International Journal of Molecular Medicine . 18 . 3 . 425–32 . Sep 2006 . 16865226 . 10.3892/ijmm.18.3.425 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Lee YC, Yang VC, Wang TS . Use of RAPD to detect sodium arsenite-induced DNA damage in human lymphoblastoid cells . Toxicology . 239 . 1–2 . 108–15 . Sep 2007 . 17707572 . 10.1016/j.tox.2007.06.101 .

Notes and References

1. Chano T, Ikegawa S, Kontani K, Okabe H, Baldini N, Saeki Y . Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells . Oncogene . 21 . 8 . 1295–8 . Feb 2002 . 11850849 . 10.1038/sj.onc.1205171 . 1446211 . free .
2. Maucuer A, Camonis JH, Sobel A . Stathmin interaction with a putative kinase and coiled-coil-forming protein domains . Proceedings of the National Academy of Sciences of the United States of America . 92 . 8 . 3100–4 . Apr 1995 . 7724523 . 42112 . 10.1073/pnas.92.8.3100 . 1995PNAS...92.3100M . free .
3. Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N . FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells . The Journal of Cell Biology . 181 . 3 . 497–510 . May 2008 . 18443221 . 2364687 . 10.1083/jcb.200712064 .
4. Web site: Entrez Gene: RB1CC1 RB1-inducible coiled-coil 1.
5. Ueda H, Abbi S, Zheng C, Guan JL . Suppression of Pyk2 kinase and cellular activities by FIP200 . The Journal of Cell Biology . 149 . 2 . 423–30 . Apr 2000 . 10769033 . 2175150 . 10.1083/jcb.149.2.423 .
6. Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL . Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways . The Journal of Cell Biology . 175 . 1 . 121–33 . Oct 2006 . 17015619 . 2064504 . 10.1083/jcb.200604129 .