FIBP explained

Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene.^{[1] [2]}

Function

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.^[2]

Interactions

FIBP has been shown to interact with FGF1.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Kolpakova E, Frengen E, Stokke T, Olsnes S . Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein . Biochem. J. . 352 . 3 . 629–35 . 2000 . 11104667 . 1221498 . 10.1042/0264-6021:3520629 .
• Tassi E, Al-Attar A, Aigner A, Swift MR, McDonnell K, Karavanov A, Wellstein A . Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein . J. Biol. Chem. . 276 . 43 . 40247–53 . 2001 . 11509569 . 10.1074/jbc.M104933200 . free .
• Skjerpen CS, Nilsen T, Wesche J, Olsnes S . Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity . EMBO J. . 21 . 15 . 4058–69 . 2002 . 12145206 . 126148 . 10.1093/emboj/cdf402 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Kolpakova . E . Wiedłocha . A . Stenmark . H . Klingenberg . O . Faines. PO. Olsnes. S. 15 November 1998 . Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor . Biochem. J. . 336 . 1. 213–22 . 9806903. 1219860. 10.1042/bj3360213.
2. Web site: Entrez Gene: FIBP fibroblast growth factor (acidic) intracellular binding protein . ncbi.nlm.nih.gov.