FHL5 explained

Four and a half LIM domains protein 5 is a protein that in humans is encoded by the FHL5 gene.^[1]

Function

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene.

Interactions

FHL5 has been shown to interact with CREB1^[2] and CAMP responsive element modulator.^{[2] [3]}

Further reading

• Fimia GM, Morlon A, Macho B, De Cesare D, Sassone-Corsi P . Transcriptional cascades during spermatogenesis: pivotal role of CREM and ACT . Mol. Cell. Endocrinol. . 179 . 1–2 . 17–23 . 2001 . 11420126 . 10.1016/S0303-7207(01)00463-4 . 34999951 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Fimia GM, De Cesare D, Sassone-Corsi P . CBP-independent activation of CREM and CREB by the LIM-only protein ACT . Nature . 398 . 6723 . 165–9 . 1999 . 10086359 . 10.1038/18237 . 1999Natur.398..165F . 4424908 .
• Fimia GM, De Cesare D, Sassone-Corsi P . A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM . Mol. Cell. Biol. . 20 . 22 . 8613–22 . 2000 . 11046156 . 102166 . 10.1128/MCB.20.22.8613-8622.2000 .
• Palermo I, Litrico L, Emmanuele G, Giuffrida V, Sassone-Corsi P, De Cesare D, Maria Fimia G, D'Agata R, Calogero AE, Travali S . Cloning and expression of activator of CREM in testis in human testicular tissue . Biochem. Biophys. Res. Commun. . 283 . 2 . 406–11 . 2001 . 11327716 . 10.1006/bbrc.2001.4805 .
• Peri A, Luciani P, Tonacchera M, Agretti P, Baglioni-Peri S, Buci L, Conforti B, Cioppi F, Biliotti G, Serio M, Vitti P, Chiovato L . Expression of cAMP-responsive element binding protein and inducible cAMP early repressor in hyperfunctioning thyroid adenomas . Eur. J. Endocrinol. . 146 . 6 . 759–66 . 2002 . 12039695 . 10.1530/eje.0.1460759 . free .
• Macho B, Brancorsini S, Fimia GM, Setou M, Hirokawa N, Sassone-Corsi P . CREM-dependent transcription in male germ cells controlled by a kinesin . Science . 298 . 5602 . 2388–90 . 2002 . 12493914 . 10.1126/science.1077265 . 2002Sci...298.2388M . 42448155 .
• Philippar U, Schratt G, Dieterich C, Müller JM, Galgóczy P, Engel FB, Keating MT, Gertler F, Schüle R, Vingron M, Nordheim A . The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF . Mol. Cell . 16 . 6 . 867–80 . 2004 . 15610731 . 10.1016/j.molcel.2004.11.039 . 1721.1/83480 . free .
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL . High-throughput mapping of a dynamic signaling network in mammalian cells . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Christensen GL, Wooding SP, Ivanov IP, Atkins JF, Carrell DT . Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males . Mol. Hum. Reprod. . 12 . 4 . 257–62 . 2006 . 16687568 . 10.1093/molehr/gal006 . free .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .

Notes and References

1. Web site: Entrez Gene: FHL5 four and a half LIM domains 5.
2. Fimia GM, De Cesare D, Sassone-Corsi P . A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM . Mol. Cell. Biol. . 20 . 22 . 8613–22 . November 2000 . 11046156 . 102166 . 10.1128/MCB.20.22.8613-8622.2000 .
3. Fimia GM, De Cesare D, Sassone-Corsi P . CBP-independent activation of CREM and CREB by the LIM-only protein ACT . Nature . 398 . 6723 . 165–9 . March 1999 . 10086359 . 10.1038/18237 . 1999Natur.398..165F . 4424908 .