FGFR1OP explained

FGFR1 oncogene partner is a protein that in humans is encoded by the FGFR1OP gene.^{[1] [2] [3]}

Function

This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.^[4]

Further reading

• Guasch G, Ollendorff V, Borg JP, Birnbaum D, Pébusque MJ . 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways . Molecular and Cellular Biology . 21 . 23 . 8129–42 . December 2001 . 11689702 . 99978 . 10.1128/MCB.21.23.8129-8142.2001 .
• Guasch G, Delaval B, Arnoulet C, Xie MJ, Xerri L, Sainty D, Birnbaum D, Pébusque MJ . FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice . Blood . 103 . 1 . 309–12 . January 2004 . 12969958 . 10.1182/blood-2003-05-1690 . 30338542 .
• Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M . Proteomic characterization of the human centrosome by protein correlation profiling . Nature . 426 . 6966 . 570–4 . December 2003 . 14654843 . 10.1038/nature02166 . 2003Natur.426..570A . 4427303 .
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry . Analytical Chemistry . 76 . 10 . 2763–72 . May 2004 . 15144186 . 10.1021/ac035352d .
• Yan X, Habedanck R, Nigg EA . A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring . Molecular Biology of the Cell . 17 . 2 . 634–44 . February 2006 . 16314388 . 1356575 . 10.1091/mbc.E05-08-0810 .
• Mikolajka A, Yan X, Popowicz GM, Smialowski P, Nigg EA, Holak TA . Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization . Journal of Molecular Biology . 359 . 4 . 863–75 . June 2006 . 16690081 . 10.1016/j.jmb.2006.03.070 .
• Mano Y, Takahashi K, Ishikawa N, Takano A, Yasui W, Inai K, Nishimura H, Tsuchiya E, Nakamura Y, Daigo Y . Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer . Cancer Science . 98 . 12 . 1902–13 . December 2007 . 17888034 . 10.1111/j.1349-7006.2007.00610.x . 22416517 . 11159412 .

Notes and References

1. Popovici C, Zhang B, Grégoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pébusque MJ . The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1 . Blood . 93 . 4 . 1381–9 . February 1999 . 9949182 . 10.1182/blood.V93.4.1381.
2. Reither A, Hehlmann R, Goldman JM, Cross NC . [The 8p11 myeloproliferative syndrome] . Medizinische Klinik . 94 . 4 . 207–10 . April 1999 . 10373756 . 10.1007/BF03044856. 6808400 .
3. Web site: Entrez Gene: FGFR1OP FGFR1 oncogene partner.
4. Web site: Entrez Gene: FGFR1OP FGFR1 oncogene partner.