FGFBP1 explained

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.^{[1] [2] [3]}

FGFBP1, or HBP17, binds to both acidic FGF1 and basic FGF2 fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2).[supplied by OMIM]^[4]

Interactions

FGFBP1 has been shown to interaction with Perlecan.

Further reading

• Abuharbeid S, Czubayko F, Aigner A . The fibroblast growth factor-binding protein FGF-BP. . Int. J. Biochem. Cell Biol. . 38 . 9 . 1463–8 . 2006 . 16324873 . 10.1016/j.biocel.2005.10.017 .
• Lange LG, Sytkowski AJ, Vallee BL . Human liver alcohol dehydrogenase: purification, composition, and catalytic features. . Biochemistry . 15 . 21 . 4687–93 . 1976 . 9982 . 10.1021/bi00666a023 .
• Czubayko F, Liaudet-Coopman ED, Aigner A . A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. . Nat. Med. . 3 . 10 . 1137–40 . 1997 . 9334727 . 10.1038/nm1097-1137 . 3633113 . etal.
• Wang XC, Chen JH, Crab JW, Sato JD . Purification of heparin-binding protein HBp17 and identification of HBp17 heparin binding site. . Biochem. Mol. Biol. Int. . 46 . 1 . 81–7 . 1998 . 9784842 . 10.1080/15216549800203582. 44789730 . free .
• Harris VK, Coticchia CM, Kagan BL . Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways. . J. Biol. Chem. . 275 . 15 . 10802–11 . 2000 . 10753873 . 10.1074/jbc.275.15.10802 . etal. free .
• Sauter ER, Nesbit M, Tichansky D . Fibroblast growth factor-binding protein expression changes with disease progression in clinical and experimental human squamous epithelium. . Int. J. Cancer . 92 . 3 . 374–81 . 2001 . 11291074 . 10.1002/ijc.1207 . 20415335 . etal. free .
• Chen JH, Wang XC, Sato JD . Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells. . Cell Biol. Int. . 25 . 6 . 567–70 . 2001 . 11407864 . 10.1006/cbir.2000.0688 . 19909718 .
• Tassi E, Al-Attar A, Aigner A . Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein. . J. Biol. Chem. . 276 . 43 . 40247–53 . 2001 . 11509569 . 10.1074/jbc.M104933200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Beer HD, Bittner M, Niklaus G . The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. . Oncogene . 24 . 34 . 5269–77 . 2005 . 15806171 . 10.1038/sj.onc.1208560 . etal. 75364 .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Xie B, Tassi E, Swift MR . Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. . J. Biol. Chem. . 281 . 2 . 1137–44 . 2006 . 16257968 . 10.1074/jbc.M510754200 . etal. free .
• Ray PE, Tassi E, Liu XH, Wellstein A . Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome. . Am. J. Physiol. Regul. Integr. Comp. Physiol. . 290 . 1 . R105–13 . 2006 . 16352855 . 10.1152/ajpregu.00492.2005 . 25248653 .
• Lim J, Hao T, Shaw C . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . etal. free .

Notes and References

1. Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV . Fibroblast growth factor-binding protein is a novel partner for perlecan protein core . J Biol Chem . 276 . 13 . 10263–71 . Mar 2001 . 11148217 . 10.1074/jbc.M011493200 . free .
2. Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD . Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors . J Biol Chem . 266 . 25 . 16778–85 . Oct 1991 . 10.1016/S0021-9258(18)55368-0 . 1885605 . free .
3. Web site: Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1.
4. Web site: Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1.