FGF6 explained

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.^{[1] [2]}

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation.

Further reading

• Vainikka S, Partanen J, Bellosta P . Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction. . EMBO J. . 11 . 12 . 4273–80 . 1992 . 1385111 . 10.1002/j.1460-2075.1992.tb05526.x. 557000 . etal.
• Iida S, Yoshida T, Naito K . Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization. . Oncogene . 7 . 2 . 303–9 . 1992 . 1549352 . etal.
• Coulier F, Batoz M, Marics I . Putative structure of the FGF6 gene product and role of the signal peptide. . Oncogene . 6 . 8 . 1437–44 . 1991 . 1886714 . etal.
• Marics I, Adelaide J, Raybaud F . Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family. . Oncogene . 4 . 3 . 335–40 . 1989 . 2649847 . etal.
• Aerssens J, Chaffanet M, Baens M . Regional assignment of seven loci to 12p13.2-pter by PCR analysis of somatic cell hybrids containing the der(12) or the der(X) chromosome from a mesothelioma showing t(X;12)(q22;p13). . Genomics . 20 . 1 . 119–21 . 1994 . 8020938 . 10.1006/geno.1994.1136 . etal.
• Ornitz DM, Xu J, Colvin JS . Receptor specificity of the fibroblast growth factor family. . J. Biol. Chem. . 271 . 25 . 15292–7 . 1996 . 8663044 . 10.1074/jbc.271.25.15292 . etal. free .
• Ropiquet F, Giri D, Kwabi-Addo B . Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. . Cancer Res. . 60 . 15 . 4245–50 . 2000 . 10945637 . etal.
• Duplan SM, Théorêt Y, Kenigsberg RL . Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor variant. . Clin. Cancer Res. . 8 . 1 . 246–57 . 2002 . 11801566 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Popovici C, Conchonaud F, Birnbaum D, Roubin R . Functional phylogeny relates LET-756 to fibroblast growth factor 9. . J. Biol. Chem. . 279 . 38 . 40146–52 . 2004 . 15199049 . 10.1074/jbc.M405795200 . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM . Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family . J Biol Chem . 281 . 23 . 15694–700 . Jun 2006 . 16597617 . 2080618 . 10.1074/jbc.M601252200 . free .
2. Web site: Entrez Gene: FGF6 fibroblast growth factor 6.