FGF20 explained

fibroblast growth factor 20
Hgncid:3677
Symbol:FGF20
Entrezgene:26281
Omim:605558
Refseq:NM_019851
Uniprot:Q9NP95
Chromosome:8
Arm:p
Band:22

Fibroblast growth factor 20 is a protein which in humans is encoded by the FGF20 gene.[1]

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development,[2] cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be expressed in normal brain, particularly the cerebellum. The rat homolog is preferentially expressed in the brain and able to enhance the survival of midbrain dopaminergic neurons in vitro.[3]

Notes and References

  1. Kirikoshi H, Sagara N, Saitoh T, Tanaka K, Sekihara H, Shiokawa K, Katoh M . Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22 . Biochemical and Biophysical Research Communications . 274 . 2 . 337–43 . August 2000 . 10913340 . 10.1006/bbrc.2000.3142 .
  2. Koga C, Adati N, Nakata K, Mikoshiba K, Furuhata Y, Sato S, Tei H, Sakaki Y, Kurokawa T . Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis . Biochemical and Biophysical Research Communications . 261 . 3 . 756–65 . August 1999 . 10441498 . 10.1006/bbrc.1999.1039.
  3. Web site: Entrez Gene: Fibroblast growth factor 20.