FGF17 explained

Fibroblast growth factor 17 is a protein that in humans is encoded by the FGF17 gene.^{[1] [2]}

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes, including embryonic development cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene was shown to be prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular development. This gene was referred to as FGF-13 in reference 2, however, its amino acid sequence and chromosomal localization are identical to FGF17.^[3]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Xu J, Lawshe A, MacArthur CA, Ornitz DM . Genomic structure, mapping, activity and expression of fibroblast growth factor 17. . Mech. Dev. . 83 . 1–2 . 165–78 . 1999 . 10381577 . 10.1016/S0925-4773(99)00034-9 . 14538640 .
• Xu J, Liu Z, Ornitz DM . Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures . Development . 127 . 9 . 1833–43 . 2000 . 10.1242/dev.127.9.1833 . 10751172 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Clark HF, Gurney AL, Abaya E . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Polnaszek N, Kwabi-Addo B, Wang J, Ittmann M . FGF17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasia . Prostate . 60 . 1 . 18–24 . 2004 . 15129425 . 10.1002/pros.20026 . 22340970 .
• Popovici C, Conchonaud F, Birnbaum D, Roubin R . Functional phylogeny relates LET-756 to fibroblast growth factor 9 . J. Biol. Chem. . 279 . 38 . 40146–52 . 2004 . 15199049 . 10.1074/jbc.M405795200 . free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Iram T, Kern F, Kaur A, Myneni S, Morningstar AR, Shin H, Wyss-Coray T. Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17 . Nature . 605. 7910. 509–515. 2022 . 35545674 . 10.1038/s41586-022-04722-0 . 9377328. 2022Natur.605..509I . etal.

Notes and References

1. Hoshikawa M, Ohbayashi N, Yonamine A, Konishi M, Ozaki K, Fukui S, Itoh N . Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain . Biochem Biophys Res Commun . 244 . 1 . 187–91 . Apr 1998 . 9514906 . 10.1006/bbrc.1998.8239 . free .
2. Greene JM, Li YL, Yourey PA, Gruber J, Carter KC, Shell BK, Dillon PA, Florence C, Duan DR, Blunt A, Ornitz DM, Ruben SM, Alderson RF . Identification and characterization of a novel member of the fibroblast growth factor family . Eur J Neurosci . 10 . 5 . 1911–25 . Oct 1998 . 9751161 . 10.1046/j.1460-9568.1998.00211.x . 26104531 . free .
3. Web site: Entrez Gene: FGF17 fibroblast growth factor 17.