FGD2 explained

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.^[1]

It is a member of the FYVE, RhoGEF and PH domain containing family.

See also

• FYVE domain (zinc finger domain)
• RhoGEF domain (with guanine nucleotide exchange factor activity)
• PH domain (pleckstrin homology domain)

Further reading

• Salehi AH, Xanthoudakis S, Barker PA . NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway. . J. Biol. Chem. . 277 . 50 . 48043–50 . 2002 . 12376548 . 10.1074/jbc.M205324200 . free .
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Hattori A, Okumura K, Nagase T . Characterization of long cDNA clones from human adult spleen. . DNA Res. . 7 . 6 . 357–66 . 2000 . 11214971 . 10.1093/dnares/7.6.357. etal. free .
• Pasteris NG, Gorski JL . Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues. . Genomics . 60 . 1 . 57–66 . 1999 . 10458911 . 10.1006/geno.1999.5903 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Harrington AW, Kim JY, Yoon SO . Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis. . J. Neurosci. . 22 . 1 . 156–66 . 2002 . 11756498 . 10.1523/JNEUROSCI.22-01-00156.2002. 6757583 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Rabizadeh S, Bredesen DE . Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR). . Cytokine Growth Factor Rev. . 14 . 3–4 . 225–39 . 2003. 12787561 . 10.1016/S1359-6101(03)00018-2.
• Huber C, Mårtensson A, Bokoch GM . FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles. . J. Biol. Chem. . 283 . 49 . 34002–12 . 2008 . 18838382 . 10.1074/jbc.M803957200 . 2590680. etal. free .
• Delague V, Jacquier A, Hamadouche T . Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H. . Am. J. Hum. Genet. . 81 . 1 . 1–16 . 2007 . 17564959 . 10.1086/518428 . 1950914. etal.

Notes and References

1. Web site: Entrez Gene: FYVE.