FEZ2 explained

Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene.^{[1] [2]}

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin.

Interactions

FEZ2 has been shown to interact with Protein kinase Mζ.^[3]

Further reading

• Ranes-Goldberg MG, Hori T, Mohan-Peterson S, Spits H . Identification of human pre-T/NK cell-associated genes . J. Immunol. . 151 . 10 . 5810–21 . 1993 . 10.4049/jimmunol.151.10.5810 . 8228263 . 39286195 .
• Kolle G, Georgas K, Holmes GP . CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis . Mech. Dev. . 90 . 2 . 181–93 . 2000 . 10642437 . 10.1016/S0925-4773(99)00248-8 . 6529349 . etal. free .
• Hu RM, Han ZG, Song HD . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–8 . 2000 . 10931946 . 10.1073/pnas.160270997 . 16901 . etal. 2000PNAS...97.9543H . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Surpili MJ, Delben TM, Kobarg J . Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1 . Biochemistry . 42 . 51 . 15369–76 . 2004 . 14690447 . 10.1021/bi034575v .
• Fujita T, Ikuta J, Hamada J . Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1 . Biochem. Biophys. Res. Commun. . 313 . 3 . 738–44 . 2004 . 14697253 . 10.1016/j.bbrc.2003.12.006 . etal.
• Hillier LW, Graves TA, Fulton RS . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . etal. 2005Natur.434..724H . free .
• Assmann EM, Alborghetti MR, Camargo ME, Kobarg J . FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region . J. Biol. Chem. . 281 . 15 . 9869–81 . 2006 . 16484223 . 10.1074/jbc.M513280200 . free .

Notes and References

1. Bloom L, Horvitz HR . The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation . Proc Natl Acad Sci U S A . 94 . 7 . 3414–9 . May 1997 . 9096408 . 20384 . 10.1073/pnas.94.7.3414 . 1997PNAS...94.3414B . free .
2. Web site: Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II).
3. 10.1016/j.bbrc.2003.12.006 . Fujita . Toshitsugu . Ikuta Junko . Hamada Juri . Okajima Toshihide . Tatematsu Kenji . Tanizawa Katsuyuki . Kuroda Shun'ichi . Jan 2004 . Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1 . Biochem. Biophys. Res. Commun. . 313 . 3 . 738–44 . United States. 0006-291X. 14697253 .