FER (gene) explained

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.^[1]

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.

Interactions

FER (gene) has been shown to interact with TMF1^[2] and Cortactin.^[3]

Further reading

• Greer P . Closing in on the biological functions of Fps/Fes and Fer . Nat. Rev. Mol. Cell Biol. . 3 . 4 . 278–89 . 2002 . 11994747 . 10.1038/nrm783 . 22927394 .
• Nishisho I, Nakamura Y, Miyoshi Y . Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients . Science . 253 . 5020 . 665–9 . 1991 . 1651563 . 10.1126/science.1651563 . etal. 1991Sci...253..665N .
• Warrington JA, Hall LV, Hinton LM . Radiation hybrid map of 13 loci on the long arm of chromosome 5 . Genomics . 11 . 3 . 701–8 . 1992 . 1663488 . 10.1016/0888-7543(91)90078-S . etal.
• Hao QL, Ferris DK, White G . Nuclear and cytoplasmic location of the FER tyrosine kinase . Mol. Cell. Biol. . 11 . 2 . 1180–3 . 1991 . 1990274 . 10.1128/mcb.11.2.1180. 359807 . etal.
• Krolewski JJ, Lee R, Eddy R . Identification and chromosomal mapping of new human tyrosine kinase genes . Oncogene . 5 . 3 . 277–82 . 1990 . 2156206 . etal.
• Morris C, Heisterkamp N, Hao QL . The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q) . Cytogenet. Cell Genet. . 53 . 4 . 196–200 . 1990 . 2209086 . 10.1159/000132929 . etal.
• Pawson T, Letwin K, Lee T . The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family . Mol. Cell. Biol. . 9 . 12 . 5722–5 . 1990 . 2685575 . 10.1128/mcb.9.12.5722. 363745 . etal.
• Hao QL, Heisterkamp N, Groffen J . Isolation and sequence analysis of a novel human tyrosine kinase gene . Mol. Cell. Biol. . 9 . 4 . 1587–93 . 1989 . 2725517 . 10.1128/mcb.9.4.1587. 362575 .
• Brunati AM, Pinna LA . Characterization of four tyrosine protein kinases from the particulate fraction of rat spleen . Eur. J. Biochem. . 172 . 2 . 451–7 . 1988 . 3350007 . 10.1111/j.1432-1033.1988.tb13909.x . free .
• Meggio F, Brunati AM, Pinna LA . Polycation-dependent, Ca2+-antagonized phosphorylation of calmodulin by casein kinase-2 and a spleen tyrosine protein kinase . FEBS Lett. . 215 . 2 . 241–6 . 1987 . 3472906 . 10.1016/0014-5793(87)80154-0 . 2801487 . free .
• Kim L, Wong TW . The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors . Mol. Cell. Biol. . 15 . 8 . 4553–61 . 1995 . 7623846 . 10.1128/mcb.15.8.4553. 230695 .
• Lee ST, Strunk KM, Spritz RA . A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes . Oncogene . 8 . 12 . 3403–10 . 1993 . 8247543 .
• Kim L, Wong TW . Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER . J. Biol. Chem. . 273 . 36 . 23542–8 . 1998 . 9722593 . 10.1074/jbc.273.36.23542 . free .
• Rosato R, Veltmaat JM, Groffen J, Heisterkamp N . Involvement of the tyrosine kinase fer in cell adhesion . Mol. Cell. Biol. . 18 . 10 . 5762–70 . 1998 . 9742093 . 10.1128/mcb.18.10.5762. 109162 .
• Schwartz Y, Ben-Dor I, Navon A . Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases . FEBS Lett. . 434 . 3 . 339–45 . 1998 . 9742951 . 10.1016/S0014-5793(98)01003-5 . 24338520 . etal. free .
• Huang C, Liu J, Haudenschild CC, Zhan X . The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells . J. Biol. Chem. . 273 . 40 . 25770–6 . 1998 . 9748248 . 10.1074/jbc.273.40.25770 . free .
• Corti C, Leclerc L'Hostis E, Quadroni M . Tyrosine phosphorylation modulates the interaction of calmodulin with its target proteins . Eur. J. Biochem. . 262 . 3 . 790–802 . 1999 . 10411641 . 10.1046/j.1432-1327.1999.00441.x . etal. free .
• Priel-Halachmi S, Ben-Dor I, Shpungin S . FER kinase activation of Stat3 is determined by the N-terminal sequence . J. Biol. Chem. . 275 . 37 . 28902–10 . 2000 . 10878010 . 10.1074/jbc.M003402200 . etal. free .
• Kapus A, Di Ciano C, Sun J . Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases . J. Biol. Chem. . 275 . 41 . 32289–98 . 2000 . 10921917 . 10.1074/jbc.M003172200 . etal. free .
• Orlovsky K, Ben-Dor I, Priel-Halachmi S . N-terminal sequences direct the autophosphorylation states of the FER tyrosine kinases in vivo . Biochemistry . 39 . 36 . 11084–91 . 2000 . 10998246 . 10.1021/bi0005153 . etal.

Notes and References

1. Web site: Entrez Gene: FER fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94).
2. Schwartz . Y . Ben-Dor I . Navon A . Motro B . Nir U . Sep 1998 . Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases . FEBS Lett. . 434 . 3 . 339–45 . NETHERLANDS. 0014-5793. 9742951 . 10.1016/S0014-5793(98)01003-5 . 24338520 . free .
3. Kim . L . Wong T W . Sep 1998 . Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER . J. Biol. Chem. . 273 . 36 . 23542–8 . UNITED STATES. 0021-9258. 9722593 . 10.1074/jbc.273.36.23542 . free .