FDX2 explained

Ferredoxin 2 is a protein that in humans is encoded by the FDX2 gene. It participates in heme A synthesis and iron-sulphur protein synthesis.^[1]

Mutations in FDX2 cause mitochondrial myopathy.^[2]

Further reading

• Sheftel AD, Stehling O, Pierik AJ, Elsässer HP, Mühlenhoff U, Webert H, Hobler A, Hannemann F, Bernhardt R, Lill R . Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis . Proceedings of the National Academy of Sciences of the United States of America . 107 . 26 . 11775–80 . June 2010 . 20547883 . 2900682 . 10.1073/pnas.1004250107 . 2010PNAS..10711775S . free .

Notes and References

1. Web site: Entrez Gene: Ferredoxin 2 .
2. Spiegel R, Saada A, Halvardson J, Soiferman D, Shaag A, Edvardson S, Horovitz Y, Khayat M, Shalev SA, Feuk L, Elpeleg O . Deleterious mutation in FDX1L gene is associated with a novel mitochondrial muscle myopathy . European Journal of Human Genetics . 22 . 7 . 902–6 . July 2014 . 24281368 . 10.1038/ejhg.2013.269 . 4060119 .