FCRLA explained

Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene.^{[1] [2]}

Receptors for the Fc fragment of IgG, or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. All FCGR genes map to human chromosome 1. Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis.[supplied by OMIM]

Further reading

• Facchetti F, Cella M, Festa S . An unusual Fc receptor-related protein expressed in human centroblasts . Proc. Natl. Acad. Sci. U.S.A. . 99 . 6 . 3776–81 . 2002 . 11891275 . 10.1073/pnas.022042699 . 122600 . 2002PNAS...99.3776F . etal. free .
• Davis RS, Li H, Chen CC . Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells . Int. Immunol. . 14 . 9 . 1075–83 . 2003 . 12202404 . 10.1093/intimm/dxf074 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Huizinga TW, Ioan-Facsinay A . Soluble FcgammaRIIIa as a marker for rheumatoid arthritis: the use of genetics in selected populations to study pathogenetic pathways . J. Rheumatol. . 30 . 9 . 1904–6 . 2004 . 12966588 .
• Clark HF, Gurney AL, Abaya E . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Inozume T, Matsuzaki Y, Kurihara S . Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients . Int. J. Cancer . 114 . 2 . 283–90 . 2005 . 15551350 . 10.1002/ijc.20735 . etal. free .
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .
• Taylor AI, Gould HJ, Sutton BJ, Calvert RA . The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL . Immunogenetics . 59 . 4 . 323–8 . 2007 . 17273841 . 10.1007/s00251-007-0195-9 . 1971426 .

Notes and References

1. Mechetina LV, Najakshin AM, Volkova OY, Guselnikov SV, Faizulin RZ, Alabyev BY, Chikaev NA, Vinogradova MS, Taranin AV . FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features . Eur J Immunol . 32 . 1 . 87–96 . Dec 2001 . 11754007 . 10.1002/1521-4141(200201)32:1<87::AID-IMMU87>3.0.CO;2-# . 196599868 .
2. Web site: Entrez Gene: FCRLA Fc receptor-like A.