FCRL4 explained
Fc receptor-like protein 4 is a protein that in humans is encoded by the FCRL4 gene. FCRL4 is an inhibitory receptor expressed on human memory B cells which resides in epithelial tissues.[1] [2] [3]
Further reading
- Taylor AI, Gould HJ, Sutton BJ, Calvert RA . The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL . Immunogenetics . 59 . 4 . 323–8 . 2007 . 17273841 . 10.1007/s00251-007-0195-9 . 1971426 .
- Ehrhardt GR, Hsu JT, Gartland L . Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells . J. Exp. Med. . 202 . 6 . 783–91 . 2005 . 16157685 . 10.1084/jem.20050879 . 2212938 . etal.
- Jöhrens K, Shimizu Y, Anagnostopoulos I . T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution . Haematologica . 90 . 8 . 1070–7 . 2006 . 16079106 . etal.
- Falini B, Tiacci E, Pucciarini A . Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT) . Blood . 102 . 10 . 3684–92 . 2004 . 12881317 . 10.1182/blood-2003-03-0750 . etal. free .
- Guselnikov SV, Ershova SA, Mechetina LV . A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1 . Immunogenetics . 54 . 2 . 87–95 . 2002 . 12037601 . 10.1007/s00251-002-0436-x . 9452957 . etal.
- Miller I, Hatzivassiliou G, Cattoretti G . IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells . Blood . 99 . 8 . 2662–9 . 2002 . 11929751 . 10.1182/blood.V99.8.2662 . etal. free .
Notes and References
- Hatzivassiliou G, Miller I, Takizawa J, Palanisamy N, Rao PH, Iida S, Tagawa S, Taniwaki M, Russo J, Neri A, Cattoretti G, Clynes R, Mendelsohn C, Chaganti RS, Dalla-Favera R . IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy . Immunity . 14 . 3 . 277–89 . Apr 2001 . 11290337 . 10.1016/S1074-7613(01)00109-1 . free .
- Davis RS, Wang YH, Kubagawa H, Cooper MD . Identification of a family of Fc receptor homologs with preferential B cell expression . Proc Natl Acad Sci U S A . 98 . 17 . 9772–7 . Aug 2001 . 11493702 . 55528 . 10.1073/pnas.171308498 . 2001PNAS...98.9772D . free .
- Web site: Entrez Gene: FCRL4 Fc receptor-like 4.