FCGR2A explained

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.^{[1] [2]}

Interactions

FCGR2A has been shown to interact with PIK3R1^{[3] [4]} and Syk.^{[4] [5]}

See also

• CD32

Further reading

• McKenzie SE . Humanized mouse models of FcR clearance in immune platelet disorders. . Blood Rev. . 16 . 1 . 3–5 . 2002 . 11913983 . 10.1054/blre.2001.0170 .
• Ernst LK, van de Winkel JG, Chiu IM, Anderson CL . Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. . J. Biol. Chem. . 267 . 22 . 15692–700 . 1992 . 10.1016/S0021-9258(19)49591-4 . 1379234 . free .
• Seki T . Identification of multiple isoforms of the low-affinity human IgG Fc receptor. . Immunogenetics . 30 . 1 . 5–12 . 1989 . 2526077 . 10.1007/BF02421463 . 23208039 .
• Hessian PA, Highton J, Palmer DG . Quantification of macrophage cell surface molecules in rheumatoid arthritis . Clin. Exp. Immunol. . 77 . 1 . 47–51 . 1989 . 2527651 . 1541930 .
• Brooks DG, Qiu WQ, Luster AD, Ravetch JV . Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes . J. Exp. Med. . 170 . 4 . 1369–85 . 1989 . 2529342 . 10.1084/jem.170.4.1369 . 2189488 .
• Lanier LL, Cwirla S, Yu G . Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid . Science . 246 . 4937 . 1611–3 . 1990 . 2531919 . 10.1126/science.2531919 . etal. 1989Sci...246.1611L .
• Stuart SG, Trounstine ML, Vaux DJ . Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII) . J. Exp. Med. . 166 . 6 . 1668–84 . 1987 . 2824655 . 10.1084/jem.166.6.1668 . 2188792 . etal.
• Hibbs ML, Bonadonna L, Scott BM . Molecular cloning of a human immunoglobulin G Fc receptor . Proc. Natl. Acad. Sci. U.S.A. . 85 . 7 . 2240–4 . 1988 . 2965389 . 10.1073/pnas.85.7.2240 . 279966 . etal. 1988PNAS...85.2240H. free .
• Huizinga TW, van der Schoot CE, Jost C . The PI-linked receptor FcRIII is released on stimulation of neutrophils . Nature . 333 . 6174 . 667–9 . 1988 . 2967437 . 10.1038/333667a0 . etal. 1988Natur.333..667H . 4342856 .
• Sammartino L, Webber LM, Hogarth PM . Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1 . Immunogenetics . 28 . 5 . 380–1 . 1988 . 2971615 . 10.1007/BF00364238 . 35705081 . etal.
• Stengelin S, Stamenkovic I, Seed B . Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning . EMBO J. . 7 . 4 . 1053–9 . 1988 . 3402431 . 10.1002/j.1460-2075.1988.tb02913.x. 454434 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Chacko GW, Brandt JT, Coggeshall KM, Anderson CL . Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides . J. Biol. Chem. . 271 . 18 . 10775–81 . 1996 . 8631888 . 10.1074/jbc.271.18.10775 . free .
• Salmon JE, Millard S, Schachter LA . Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans . J. Clin. Invest. . 97 . 5 . 1348–54 . 1996 . 8636449 . 10.1172/JCI118552 . 507190 . etal.
• Bewarder N, Weinrich V, Budde P . In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation . Mol. Cell. Biol. . 16 . 9 . 4735–43 . 1996 . 8756631 . 10.1128/MCB.16.9.4735. 231474 . etal.
• Sármay G, Koncz G, Gergely J . Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway . J. Biol. Chem. . 271 . 48 . 30499–504 . 1997 . 8940017 . 10.1074/jbc.271.48.30499 . free . 2437/195888 . free .
• Ibarrola I, Vossebeld PJ, Homburg CH . Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa . Biochim. Biophys. Acta . 1357 . 3 . 348–58 . 1997 . 9268059 . 10.1016/S0167-4889(97)00034-7 . etal.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• De SK, Venkateshan CN, Seth P . Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines . Blood . 91 . 6 . 2108–17 . 1998 . 9490697 . 10.1182/blood.V91.6.2108. etal. free .

External links

• • PDBe-KB provides an overview of all the structure information available in the PDB for Human Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)

Notes and References

1. Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV . Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination . Science . 248 . 4956 . 732–5 . June 1990. 2139735 . 10.1126/science.2139735 . 1990Sci...248..732Q.
2. Web site: Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32).
3. Chacko . G W . Brandt J T . Coggeshall K M . Anderson C L . May 1996. Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides . J. Biol. Chem. . 271 . 18 . 10775–81 . 0021-9258. 8631888 . 10.1074/jbc.271.18.10775 . free .
4. Ibarrola . I . Vossebeld P J . Homburg C H . Thelen M . Roos D . Verhoeven A J . July 1997. Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa . Biochim. Biophys. Acta . 1357 . 3 . 348–58 . 0006-3002. 9268059 . 10.1016/S0167-4889(97)00034-7.
5. Kim . M K . Pan X Q . Huang Z Y . Hunter S . Hwang P H . Indik Z K . Schreiber A D . January 2001. Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis . Clin. Immunol. . 98 . 1 . 125–32 . 1521-6616. 11141335 . 10.1006/clim.2000.4955 .