FCGR1A explained

High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.^{[1] [2] [3]}

Interactions

The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif.^[4]

Further reading

• Monteiro RC, Van De Winkel JG . IgA Fc receptors . Annual Review of Immunology . 21 . 177–204 . 2003 . 12524384 . 10.1146/annurev.immunol.21.120601.141011 .
• Ernst LK, van de Winkel JG, Chiu IM, Anderson CL . Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products . The Journal of Biological Chemistry . 267 . 22 . 15692–700 . Aug 1992 . 10.1016/S0021-9258(19)49591-4 . 1379234 . free .
• Benech PD, Sastry K, Iyer RR, Eichbaum QG, Raveh DP, Ezekowitz RA . Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure . The Journal of Experimental Medicine . 176 . 4 . 1115–23 . Oct 1992 . 1402657 . 2119393 . 10.1084/jem.176.4.1115 .
• Porges AJ, Redecha PB, Doebele R, Pan LC, Salmon JE, Kimberly RP . Novel Fc gamma receptor I family gene products in human mononuclear cells . The Journal of Clinical Investigation . 90 . 5 . 2102–9 . Nov 1992 . 1430234 . 443278 . 10.1172/JCI116094 .
• van de Winkel JG, Ernst LK, Anderson CL, Chiu IM . Gene organization of the human high affinity receptor for IgG, Fc gamma RI (CD64). Characterization and evidence for a second gene . The Journal of Biological Chemistry . 266 . 20 . 13449–55 . Jul 1991 . 10.1016/S0021-9258(18)98860-5 . 1830050 . free .
• Eizuru Y, Minamishima Y . Induction of Fc (IgG) receptor(s) by simian cytomegaloviruses in human embryonic lung fibroblasts . Intervirology . 29 . 6 . 339–45 . 1989 . 2852656 . 10.1159/000150065 .
• Allen JM, Seed B . Isolation and expression of functional high-affinity Fc receptor complementary DNAs . Science . 243 . 4889 . 378–81 . Jan 1989 . 2911749 . 10.1126/science.2911749 . 1989Sci...243..378A .
• Allen JM, Seed B . Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI) . Nucleic Acids Research . 16 . 24 . 11824 . Dec 1988 . 2974947 . 339124 . 10.1093/nar/16.24.11824 .
• Indik ZK, Hunter S, Huang MM, Pan XQ, Chien P, Kelly C, Levinson AI, Kimberly RP, Schreiber AD . The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI . Experimental Hematology . 22 . 7 . 599–606 . Jul 1994 . 7516890 .
• Valerius T, Repp R, de Wit TP, Berthold S, Platzer E, Kalden JR, Gramatzki M, van de Winkel JG . Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy . Blood . 82 . 3 . 931–9 . Aug 1993 . 10.1182/blood.V82.3.931.931 . 7687898 . free .
• Wang AV, Scholl PR, Geha RS . Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn . The Journal of Experimental Medicine . 180 . 3 . 1165–70 . Sep 1994 . 8064233 . 2191633 . 10.1084/jem.180.3.1165 .
• Takai S, Kasama M, Yamada K, Kai N, Hirayama N, Namiki H, Taniyama T . Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization . Human Genetics . 93 . 1 . 13–5 . Jan 1994 . 8270248 . 10.1007/BF00218905 . 24623391 .
• Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG . Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association . The Journal of Biological Chemistry . 270 . 50 . 29781–7 . Dec 1995 . 8530370 . 10.1074/jbc.270.50.29781 . free .
• De SK, Venkateshan CN, Seth P, Gajdusek DC, Gibbs CJ . Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines . Blood . 91 . 6 . 2108–17 . Mar 1998 . 9490697 . 10.1182/blood.V91.6.2108. free .
• Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL . Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI) . Journal of Immunology . 161 . 10 . 5555–63 . Nov 1998 . 10.4049/jimmunol.161.10.5555 . 9820532 .
• Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L . The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes . European Journal of Immunology . 28 . 11 . 3423–34 . Nov 1998 . 9842885 . 10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2 . free .
• Gorgani NN, Altin JG, Parish CR . Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes . . 11 . 8 . 1275–82 . Aug 1999 . 10421785 . 10.1093/intimm/11.8.1275 . free .
• Tridandapani S, Lyden TW, Smith JL, Carter JE, Coggeshall KM, Anderson CL . The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells . The Journal of Biological Chemistry . 275 . 27 . 20480–7 . Jul 2000 . 10781611 . 10.1074/jbc.M909462199 . free .

Notes and References

1. Maresco DL, Chang E, Theil KS, Francke U, Anderson CL . The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21 . Cytogenetics and Cell Genetics . 73 . 3 . 157–63 . September 1996 . 8697799 . 10.1159/000134330 .
2. Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS . Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1 . Cytogenetics and Cell Genetics . 82 . 1–2 . 71–4 . November 1998 . 9763663 . 10.1159/000015067 . 20290009 .
3. Web site: Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64).
4. The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams Pierre Bruhns Yvan Saeys Hamida Hammad and Bart N. Lambrecht FEBRUARY 2014 | VOLUME 14 Nature Reviews Immunology