FBXW8 explained

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.^{[1] [2] [3]}

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.^[4]

Further reading

• Tsutsumi T, Kuwabara H, Arai T . Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. . Mol. Cell. Biol. . 28 . 2 . 743–51 . 2008 . 17998335 . 10.1128/MCB.01665-07 . 2223430 . etal.
• Koch HB, Zhang R, Verdoodt B . Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. . Cell Cycle . 6 . 2 . 205–17 . 2007 . 17314511 . 10.4161/cc.6.2.3742. etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Watanabe N, Arai H, Nishihara Y . M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 13 . 4419–24 . 2004 . 15070733 . 10.1073/pnas.0307700101 . 384762 . 2004PNAS..101.4419W . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Dias DC, Dolios G, Wang R, Pan ZQ . CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16601–6 . 2003 . 12481031 . 10.1073/pnas.252646399 . 139190 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .

Notes and References

1. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M . Identification of a family of human F-box proteins . Curr Biol . 9 . 20 . 1177–9 . Dec 1999 . 10531035 . 10.1016/S0960-9822(00)80020-2 . 7467493 . free . 1999CBio....9.1177C .
2. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW . A family of mammalian F-box proteins . Curr Biol . 9 . 20 . 1180–2 . Dec 1999 . 10531037 . 10.1016/S0960-9822(00)80021-4 . 14341845 . free . 1999CBio....9.1180W .
3. Web site: Entrez Gene: FBXW8 F-box and WD repeat domain containing 8.
4. Web site: Entrez Gene: FBXW8 F-box and WD repeat domain containing 8.