FBXW5 explained

F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.^[1]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated Messenger RNA decay candidates, hence not represented.^[1] Well established targets of FBXW5 include TSC2^[2] and SEC23B.^[3]

Further reading

• Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M . Identification of a family of human F-box proteins . Current Biology . 9 . 20 . 1177–9 . October 1999 . 10531035 . 10.1016/S0960-9822(00)80020-2 . 7467493 . free . 1999CBio....9.1177C .
• Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW . A family of mammalian F-box proteins . Current Biology . 9 . 20 . 1180–2 . October 1999 . 10531037 . 10.1016/S0960-9822(00)80021-4 . 14341845 . free . 1999CBio....9.1180W .
• Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H . M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP . Proceedings of the National Academy of Sciences of the United States of America . 101 . 13 . 4419–24 . March 2004 . 15070733 . 384762 . 10.1073/pnas.0307700101 . 2004PNAS..101.4419W . free .

Notes and References

1. Web site: Entrez Gene: FBXW5 F-box and WD repeat domain containing 5.
2. Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y . WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase . Genes & Development . 22 . 7 . 866–71 . April 2008 . 18381890 . 2279197 . 10.1101/gad.1624008 .
3. Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, Florens L, Washburn MP, Cavasotto CN, Fenyö D, Cuervo AM, Rossi M, Pagano M . The ULK1-FBXW5-SEC23B nexus controls autophagy . eLife . 7 . December 2018 . 30596474 . 6351106 . 10.7554/eLife.42253 . free .