FBXW2 explained

F-box/WD repeat-containing protein 2 is a protein that in humans is encoded by the FBXW2 gene.^{[1] [2]}

Function

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.^[3]

Interactions

FBXW2 has been shown to interact with SKP1A.

Further reading

• Patton EE, Willems AR, Tyers M . Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis . Trends Genet. . 14 . 6 . 236–43 . 1998 . 9635407 . 10.1016/S0168-9525(98)01473-5 .
• Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW . A family of mammalian F-box proteins . Curr. Biol. . 9 . 20 . 1180–2 . 1999 . 10531037 . 10.1016/S0960-9822(00)80021-4 . 14341845 . free . 1999CBio....9.1180W .
• Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF . Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage . Nature . 426 . 6962 . 87–91 . 2003 . 14603323 . 10.1038/nature02082 . 2003Natur.426...87B . 768783 .
• Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H . M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP . Proc. Natl. Acad. Sci. U.S.A. . 101 . 13 . 4419–24 . 2004 . 15070733 . 384762 . 10.1073/pnas.0307700101 . 2004PNAS..101.4419W . free .
• Yang CS, Yu C, Chuang HC, Chang CW, Chang GD, Yao TP, Chen H . FBW2 targets GCMa to the ubiquitin-proteasome degradation system . J. Biol. Chem. . 280 . 11 . 10083–90 . 2005 . 15640526 . 10.1074/jbc.M413986200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .

Notes and References

1. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M . Identification of a family of human F-box proteins . Curr Biol . 9 . 20 . 1177–9 . Dec 1999 . 10531035 . 10.1016/S0960-9822(00)80020-2 . 7467493 . free . 1999CBio....9.1177C .
2. Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M . Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors . Cytogenet Cell Genet . 88 . 3–4 . 255–8 . Jun 2000 . 10828603 . 10.1159/000015532 . 431704 .
3. Web site: Entrez Gene: FBXW2 F-box and WD repeat domain containing 2.