FBXW10 explained

F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.^{[1] [2] [3]}

Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1, ATR kinases (Chaturvedi and ParnaiK, 2010, PMID 20498703).

1. Kennerson ML, Nassif NT, Nicholson GA . Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat . Genomics . 53 . 1 . 110–2 . Dec 1998 . 9787083 . 10.1006/geno.1998.5453 .
2. Kennerson ML, Gordon MJ, Blair IP, Nicholson GA . Single test for two hereditary neuropathies, CMT1A and HNPP . Clin Chem . 41 . 10 . 1534–5 . Dec 1995 . 7586531 . 10.1093/clinchem/41.10.1534. free .
3. Web site: Entrez Gene: FBXW10 F-box and WD repeat domain containing 10.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Jin J, Cardozo T, Lovering RC . Systematic analysis and nomenclature of mammalian F-box proteins. . Genes Dev. . 18 . 21 . 2573–80 . 2005 . 15520277 . 10.1101/gad.1255304 . 525538 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Wiemann S, Weil B, Wellenreuther R . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . etal.