FBXO2 explained

F-box only protein 2 is a protein that in humans is encoded by the FBXO2 gene.^{[1] [2] [3]}

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.

Further reading

• Erhardt JA, Hynicka W, DiBenedetto A . A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest. . J. Biol. Chem. . 273 . 52 . 35222–7 . 1999 . 9857061 . 10.1074/jbc.273.52.35222 . etal. free .
• Yoshida Y, Chiba T, Tokunaga F . E3 ubiquitin ligase that recognizes sugar chains. . Nature . 418 . 6896 . 438–42 . 2002 . 12140560 . 10.1038/nature00890 . 2002Natur.418..438Y . 4424996 . etal.
• Ilyin GP, Sérandour AL, Pigeon C . A new subfamily of structurally related human F-box proteins. . Gene . 296 . 1–2 . 11–20 . 2003 . 12383498 . 10.1016/S0378-1119(02)00867-3 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Eom CY, Lehman IR . Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway . Proc. Natl. Acad. Sci. U.S.A. . 100 . 17 . 9803–7 . 2003 . 12904574 . 10.1073/pnas.1733876100 . 187846 . 2003PNAS..100.9803E . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .

Notes and References

1. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M . Identification of a family of human F-box proteins . Curr Biol . 9 . 20 . 1177–9 . Dec 1999 . 10531035 . 10.1016/S0960-9822(00)80020-2 . 7467493 . free . 1999CBio....9.1177C .
2. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW . A family of mammalian F-box proteins . Curr Biol . 9 . 20 . 1180–2 . Dec 1999 . 10531037 . 10.1016/S0960-9822(00)80021-4 . 14341845 . free . 1999CBio....9.1180W .
3. Web site: Entrez Gene: FBXO2 F-box protein 2.